particularly difficult cases in whom standard treatment had failed. In three of them mexiletine alone controlled the arrhythmia, but only at the cost of intolerable adverse effects. Combined treatment with mexiletine and propranolol, which have different actions and different adverse effects, enables arrhythmia to be suppressed through co-operative antiarrhythmic action. Since adverse effects h...

conclusions according to the results of this study, as carbamazepine and valproate sodium consumption can result in elevated serum levels of homocysteine and decreased levels of folate and vitamin b12, and the atherogenic effect of increased serum homocysteine level is well established, the patients under these medications should be monitored for possible atherogenic effects. results finally, t...

introduction anabolic-androgenic steroids (aas), a synthetic derivate of testosterone, have become a popular drug among athletes and bodybuilders to enhance muscle mass and improve the athletic performance. many pathological effects such as hepatic and endocrine dysfunction, behavioural changes and cardiovascular complications have been reported. case report within these ast ones, we find an in...

Background: Cutaneous drug reaction seems to be relatively common The aim of the study was to recognize offending drugs, evaluate patients' characteristics and educate the patients to avoid selfadministration and re-administration of drugs. Methods: We retrospectively and prospectively analyzed data from Sina hospital in Tabriz (2000-2005) to determine the number of hospitalizations and visits ...

BACKGROUND The disposition of a pharmaceutical compound within an organism, i.e. its Absorption, Distribution, Metabolism, Excretion, Toxicity (ADMET) properties and adverse effects, critically affects late stage failure of drug candidates and has led to the withdrawal of approved drugs. Computational methods are effective approaches to reduce the number of safety issues by analyzing possible l...

A sheer amount of information about adverse effects of drugs are published in medical case reports that pose major challenges for drug safety experts to perform timely monitoring. Efficient strategies for identification and extraction of information about adverse drug effects from free-text resources are needed to support pharmacovigilance research and decision making. Therefore, this work focu...

OBJECTIVE To assess the adverse effects of multi drug therapy (MDT) in leprosy patients. METHODS A prospective and descriptive study carried out in Department of Dermatology, Government Medical College, Jagdalpur. The adverse effects were recorded on the personal record of every individual patient, filled during the course of treatment. RESULTS 176 patient's records were analysed, looking f...

background: restless and violent behaviors are common in emergency departments (eds), which need therapeutic interventions in most of the times. the first-generation anti-psychotic drugs are one of the most applicable therapeutic agents in the management of such patients, but their use has some limitations. some studies suggest midazolam as an alternative medicine. therefore, this study was per...