Present research focus on novel combination of Rifampicin, Ofloxacin and Ethambutol loaded polymeric nanoparticles for the effective eradication of isoniazid resistant species of Tuberculosis. The nanoparticles containing Rifampicin, Ethambutol and Ofloxacin were prepared by spray drying technique using biodegradable polymer PLGA through critical process as well as polymer attributes which were...

The ways of regulating adhesion fluoroplastic coatings to metal surfaces are analyzed. It has been established that polymer and modification is necessary increase the adhesive strength resistance coatings. relative impact nature on compounds – less influenced by polymer. significantly affected activation surface mechanical treatment (grinding etc.). Various methods oxidation, etching, phosphati...

It is important to achieve high strength, modulus of elasticity, good energy damping for lightweight armor materials. For this purpose, two or more similar different materials are combined at the macro level. In way, a new structure emerges that we call composite material. A in which properties components its become evident Research on production and mechanical composites meet needs developing ...

The object of research is the hydrophobization a coating based on styrene-acrylic copolymer and cellulose acetate butyrate with pyrogenic silicon dioxide. hydrophobicity or hydrophilicity surface depends mainly chemical structure its roughness. A relief hydrophilic will be wetted much more easily than flat same material, vice versa – an increase in roughness hydrophobe accompanied by pronounced...

Background and objectives: Carvacrol is one of the main pharmacologically active components of Thymus vulgaris essential oil which has shown several therapeutic effects. There are few works regarding the formulation of essential oils as oral solid dosage forms due to their liquid nature, stability and technical problems. The aim of this study was to combine the solid-d...

Liquid marbles are micro reservoirs of fluid surrounded by a powder shell. Their unique properties show promise for high-value technological applications in the medical, biotechnology, chemical and pharmaceutical industries. In this study, liquid marbles were prepared from six mixtures of water and glycerol by releasing droplets from different heights onto a loosely packed powder bed using a 1m...

Glimepiride (GMP) is poorly water soluble drug, so solubility is the main constraint for its oral bioavailability. The aim of this study was to investigate the potential of cubosomes as lipid nanocarrier to improve the solubility and sustained action of Glimepiride. Glimepiride is one of the third generation sulfonylureas used for treatment of type 2 diabetes. The rationale of this study was to...

Diamond, the hardest of all minerals, was classed as an inert material, similar to anthracite and corundum, by Gardner (1938) on the basis of intravenous injection experiments in rabbits. By intraperitoneal injection into mice Bovet (1952) produced collagenous nodules in places where much diamond dust was accumulated. But it took six months to one year for such nodules to form as against a few ...

cancer pain. The oral route is the first choice in administering medication to relieve it, but clinical experience has shown that alternative routes of administration should be employed for patients suffering from nausea and vomiting. Furthermore, as morphine is subjected to the extensive first-pass metabolism after oral administration, the rectal administration of morphine, which can partially...