OBJECTIVE To determine the prodromal symptoms of schizophrenia in the pathways to help-seeking. STUDY DESIGN A cross-sectional study. PLACE AND DURATION OF STUDY The Department of Psychiatry, the Aga Khan University, Karachi, from 2008 to 2009. METHODOLOGY A total of 93 patients were interviewed in the pathways to care of schizophrenia. The diagnosis was based on ICD-10 criteria. The path...

While investigations have sought to identify the distinct and shared contributions of anxiety and depression to neurocognitive processes in late life, less is known regarding the further contribution of worry, a unique and critical dimension of affective dysregulation. Capturing the full range of symptoms, as inspired by the NIH Research Domain Criteria (RDoC), may provide finer-grained informa...

Introduction: Antipsychotics are often used to manage the affective (manic and depressive) and psychotic symptoms of patients with schizoaffective disorder. However, it is difficult to determine whether observed improvements in depressive symptoms are achieved through effects on depressive symptoms or effects on psychotic symptoms. This analysis evaluated the effect of antipsychotic treatment o...

Individuals with schizophrenia often demonstrate theory of mind (ToM) impairment relative to healthy adults. However, the exact nature of this impairment (first- vs. second-order ToM and cognitive vs. affective ToM) and the extent to which ToM abilities deteriorate with illness chronicity is unclear. Furthermore, little is known about the relationships between clinical symptoms and ToM error ty...

Background Previous research has examined the association of affective temperaments, as measured by the TEMPS-A, with DSM bipolar disorders. However, the relation of the TEMPS-A with risk for bipolar disorder remains unclear. The present study examined the association of affective temperaments with psychopathology, personality, and functioning in a nonclinically ascertained sample of young adul...

Traumatic brain injury (TBI) has been identified as a significant health problem among veterans. Recent research demonstrates the potential interaction and magnification of symptoms of posttraumatic stress disorder (PTSD) and substance use disorders (SUD) in veterans with a history of TBI; however, there is very limited research on the co-occurrence of the three conditions. Veterans (N = 115) w...