نتایج جستجو برای: affinity ligands
تعداد نتایج: 180734 فیلتر نتایج به سال:
A major benefit of proteomic and genomic data is the potential for developing thousands of novel diagnostic and analytical tests of cells, tissues, and clinical samples. Monoclonal antibody technologies, phage display and mRNA display, are methods that could be used to generate affinity ligands against each member of the proteome. Increasingly, the challenge is not ligand generation, rather the...
The specific recognition of carbohydrate structures in biological systems (Box 5) by carbohydrate-binding proteins (lectins) is the basis of numerous intraand intercellular events ranging from the control of protein folding to cell–cell communication during development, inflammation, and cancer metastasis [1]. Investigation of carbohydrate–lectin interactions can be approached from two directio...
Drug-discovery projects frequently employ structure-based information through protein modeling and ligand docking, and there is a plethora of reports relating successful use of them in virtual screening. Hit/lead optimization, which represents the next step and the longest for the medicinal chemist, is very rarely considered. This is not surprising because lead optimization is a much more compl...
PDZ domains in general, and those of PSD-95 in particular, are emerging as promising drug targets for diseases such as ischemic stroke. We have previously shown that dimeric ligands that simultaneously target PDZ1 and PDZ2 of PSD-95 are highly potent inhibitors of PSD-95. However, PSD-95 and the related MAGUK proteins contain three consecutive PDZ domains, hence we envisioned that targeting all...
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