In this study, we investigated the role of the inducible form of heat shock protein 70 (hsp70) in the presentation of the major putative autoantigen in multiple sclerosis, myelin basic protein (MBP), in the context of appropriate MHC class II. By coimmunoprecipitation, we found that MBP is associated with hsp70 in APC in an ATP/ADP-dependent manner. Additionally, using confocal microscopy, hsp7...

Aalders JG 1627 Aas T 74 Abbou CC 1515 Abdulkarim B 2017 Abeliovich D 36 Adami H-O 678, 1317 Adams LM 1403 Adjei AA 484 Adjuvant Breast Cancer Project Belgium 1 Agelaki S 798 Aguggini S 1106 Agus V 1535 Ahern R 953 A’Hern R 1383 Aherne GW 446 Ahlner-Elmqvist M 1478 Ahmad SA 584 Ahmed A 1667 Aillet G 1831 Aine R 552 Akahira J 1731 Al-Mulla F 692, 1032 Alakhov VY 1987 Ali MS 661 Allen-Mersh TG 16...

Accelerated chemotherapy 1444 Acquired resistance 1064 ADCC 463 Adenocarcinomas 1023, 1153, 1371, 1781 Adenomatous polyposis coli 69, 98 Adjuvant chemotherapy 827, 1251 Adjuvant therapy 1437 Advanced breast cancer 141 Advanced gastrointestinal cancer 1265 Aetiology 1667 Ageing 930 Aggressive fibromatosis 98 AIDS 1298 Alcohol 46, 341, 678 Alcohol intake 1700 ALIMTA 649 Allelic imbalance 1201 Alp...

the rapid advancement of nanotechnology enables us to use nanoscale particles. this material in terms of physical, chemical and biological characteristics are unique compared to larger particles. increased cell division, apoptosis, oxidative stress has been associated with toxic effects of nano-silver. the aim of this study was to evaluate histipotological changes and enzyme activity in nanopar...

infection with hepatitis c virus (hcv) is a worldwide problem. among hcv proteins, core antigen (ag), besides its importance for diagnostic application is a prime candidate for component of a vaccine. herein, we report results of studies on production of the hydrophilic domain of core ag (2-122) in native conformation by an arabinose induction system in e.coli and the primary characterization o...

One of the more controversial and debatable issues presently confronting clinical virologists and infectious disease specialists is the application of the cytomegalovirus antigenemia (CMV-Ag) assay (pp65 antigenemia assay) as a marker and predictor of CMV disease. For example, recent reports have shown the CMV-Ag assay to be more accurate than conventional DNA PCR or the more recent nucleic aci...

With the aim of gauging their potential as conducting or superconducting materials, we examine the crystal structures and magnetic properties of the roughly one hundred binary, ternary, and quaternary Ag(II) and Ag(III) fluorides in the solid state reported up to date. The Ag(II) cation appears in these species usually in a distorted octahedral environment, either in an [AgF](+) infinite chain ...