SYNOPSIS A family with congenital thrombocytopenia is described through four generations where the mode of inheritance appears to be an autosomal dominant. Spontaneous bruising of varying severity, menorrhagia, and profuse bleeding at operation necessitating transfusion were predominant in the history. Platelet function tests were performed on the various patients. Platelet aggregation by adeno...

The infimal convolution of M-convex functions is M-convex. This is a fundamental fact in discrete convex analysis that is often useful in its application to mathematical economics and game theory. M-convexity and its variant called M-convexity are closely related to gross substitutability, and the infimal convolution operation corresponds to an aggregation. This note provides a succinct descrip...

This study was performed to assess the clopidogrel activity in inhibition of platelet aggregation in suspected angina patients on a daily dosag of 75 mg of clopidogrel for at least 7 days. This clinical trial was conducted in the outpatients department of Cardiology, Post graduate Medical Institute, Lady Reading Hospital, Peshawar from 15th October 2007 to 20th December 2007. We included 105 su...

A major problem in the formulation of therapeutic proteins is the irreversible protein aggregation. Recombinant human interferon alpha2b (rhIFN2b) has poor stability and undergoes physical degradation. The aim of this study was to investigate the effect of solution conditions on the heat-induced aggregation of rhIFNα2b. The protein was incubated for 1 h at 40°C–70°C and for up to 240 h at 50C...

A major problem in the formulation of therapeutic proteins is the irreversible protein aggregation. Recombinant human interferon alpha2b (rhIFN2b) has poor stability and undergoes physical degradation. The aim of this study was to investigate the effect of solution conditions on the heat-induced aggregation of rhIFNα2b. The protein was incubated for 1 h at 40°C–70°C and for up to 240 h at 50C...

A quantitative study of various aspects of platelet function was carried out in eight patients with typical hairy-cell leukaemia (HCL). In at least two patients platelet aggregation was convincingly reduced to more than one aggregating agent (ADP, adrenaline, collagen, thrombin, and ristocetin). Granular storage capacity for {(14)C} 5-HT was reduced in five of the six patients tested. The two p...

A wireless sensor network (WSN) has a wide range of important applications such as remote environment monitoring , target tracking etc. This has been enabled by the availability of sensors that are smaller, cheaper and intelligent. These sensor nodes are equipped with wireless interfaces with which they can communicate with one another to form a network. The design of a WSN depends significantl...

in this paper, aggregation behaviors of aqueous solutions of short chain hydrophilic ionic liquids (ils), 1 – allyl - 3 - methylimidazolium chloride ([amim]cl), 1 - ethyl - 3 - methylimidazolium chloride ([emim]cl), 1 - butyl - 3 - methylimidazolium chloride ([bmim]cl), 1 - butyl - 3 - methylimidazolium tetrafluoroborate ([bmim]bf4) were investigated using conductivity and laser light scatterin...