نتایج جستجو برای: aggressive bcc
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Basal cell carcinoma (BCC) is the most common non-melanomatous skin cancer, typically arising in sun-exposed areas such as the head and neck. Defective signaling through the Hedgehog (HH) signaling pathway forms the molecular basis for BCC. Surgery remains the mainstay of treatment. Basal cell carcinoma of the genital tract is rare as is metastatic BCC. We report a case of metastatic BCC in a y...
Basal cell carcinoma (BCC) is the most common skin cancer in humans, and although metastasis rarely occurs, the tumor cells are nevertheless able to invade and destroy the surrounding tissue. Intralesional injection of IFN-alpha has been found to be highly effective in inducing BCC regression by an unknown mechanism. We show that in untreated patients, BCC cells express CD95 ligand, but not the...
BACKGROUND The hedgehog pathway inhibitor sonidegib demonstrated meaningful tumor shrinkage in more than 90% of patients with locally advanced basal cell carcinoma (BCC) or metastatic BCC in the BCC Outcomes with LDE225 Treatment study. OBJECTIVE This report provides long-term follow-up data collected up to 12 months after the last patient was randomized. METHODS In this multicenter, random...
BACKGROUND Basal cell carcinoma (BCC) is the most common form of skin cancer and possesses various clinical features including translucency, ulceration, pigmentation, telangiectasia, and rolled borders. Accordingly, many cutaneous lesions can mimic BCCs and differential diagnosis is difficult. OBJECTIVE To clarify the differences in clinical characteristics between BCCs and BCC-mimicking lesi...
The XPD protein has a dual function, both in nucleotide excision repair and in basal transcription. We have studied the role of two nucleotide substitutions in the XPD gene, one in exon 23 leading to an amino acid substitution (Lys751Gln) and one silent in exon 6 in relation to basal cell carcinoma (BCC). Both are two-allele polymorphisms, with the nucleobases A and C at the given positions. We...
BCC: basal cell carcinoma HH: hedgehog IHC: immunohistochemistry mBCC: metastatic basal cell carcinoma SUFU: suppressor of fused INTRODUCTION Basal cell carcinoma (BCC) represents nearly 80% of nonmelanoma primary skin malignancies in the United States. However, metastatic BCC (mBCC) is exceedingly rare, difficult to treat, and associated with high mortality, yet it’s easily preventable. We rep...
Basal cell carcinoma (BCC) presents with diverse clinical features, and several morphologic and histologic variants of BCC have been reported [Sexton et al.: J Am Acad Dermatol 1990;23:1118-1126]. Linear BCC was first described as a new clinical subtype in 1985 by Lewis [Int J Dematol 1985;24:124-125]. Here, we present a case of linear BCC that we recently encountered in an elderly Japanese pat...
We report results of total energy and electronic structure calculations of fcc and bcc silver bulk and surfaces. We find that under normal conditions (positive pressure) bcc silver is not stable. However, if silver is grown with a volume per atom & 10% larger than that of the well-known fcc silver, the total energy of the bcc structure becomes below that of fcc silver. For bcc (110) a surface s...
INTRODUCTION The epidemiology of Burkholderia cepacia complex (Bcc) in cystic fibrosis (CF) is not widely known. METHODS All CF patients with Bcc between 2002 and 2011 were reviewed, and a molecular analysis of isolates was performed. RESULTS The prevalence of Bcc infection was 7.2% (18/250). Molecular analysis of 16 Bcc isolates showed 5 species (7 B. contaminans, 6 B. cepacia, 1 B. cenoce...
The finite-temperature magnetism of Ni and permalloy in body-centered-cubic bcc and face-centered-cubic fcc phases is studied theoretically using ab initio supercell calculations and Green’s function methods. The results confirm and explain the general experimental trend that the fcc phases have higher Curie temperatures than the bcc counterparts. In addition, the spin-wave stiffness constants ...
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