HYPOTHESIS Merkel cell carcinoma is a rare dermal neuroendocrine carcinoma whose optimal treatment and prognostic factors are poorly defined. We hypothesize that high-risk patients with Merkel cell carcinoma are best treated with multimodality therapy. DESIGN A retrospective review of all patients (N = 33) with Merkel cell carcinoma treated at the Massachusetts General Hospital from January 1...

This article explores the emergence of multimodality as intrinsic to the learning, teaching and assessment of English in the Twenty-First Century. With subject traditions tied to the study of language, literature and media, multimodal texts and new technologies are now accorded overdue recognition in English curriculum documents in several countries, though assessment tends to remain largely pr...

This article discusses the prospects and challenges of combining multimodality theory with distant viewing, a recent framework proposed in field digital humanities. advocates use computational methods to enable large-scale analysis visual multimodal materials, which must be nevertheless supported by theories that explain how these materials are structured. Multimodality is well-positioned suppo...

Interstitial cystitis is an increasingly common disease characterized by urgency, frequency, and pelvic pain. Its etiology is poorly understood but is likely to be multifactorial. A proposed pathophysiology describing a cascade of events, including epithelial dysfunction, mast cell activation, and neurogenic inflammation, is presented. Using this model, multimodality therapy regimens have been ...

o bjectives: the aim of this study was to determine the cementum thickness in the first molars of patients with localized aggressive periodontitis (lap) compared to healthy individuals. materials and methods: this case-control study compared eight first molar teeth af-fected by lap with eight third molar teeth of healthy individuals. the teeth were dis- infected by immersion in 10% buffered for...