AIM To define the distribution of proliferating cell nuclear antigen (PCNA) and silver staining nucleolar organiser regions (AgNORs) in Hodgkin's disease. METHODS PCNA was shown in a series of 34 cases of Hodgkin's disease using immunohistochemical methods. In a second series of 46 cases the AgNOR technique for interphase nucleolar organiser regions was studied. Both series comprised routinel...

The authors retrospectively reviewed the cytological slides of 44 histopathologically confirmed fibroepithelial lesions of the breast, of which 11 were fibroadenoma (FA), 19 benign phyllodes tumours (PTLGM), 8 borderline (PTBM) and 6 malignant (PTHGM). The 2 FA misdiagnosed as PTLGM in cytological smears were both of cellular type. NORS were quantified in a series of the above cases using the s...

Nucleolar organiser regions represent nucleolar activity in both normal and malignant cells. More numerous nucleolar organiser regions have been found in cells from many forms of malignancy than in normal cells. An argyrophilic method of staining these regions (the AgNOR technique) has been applied to specimens of pleura obtained by biopsy or at necropsy in an attempt to differentiate between n...

It has been shown that AgNOR staining can provide useful information for diagnosis in cytology of the oral cavity [22], body fluids [3,18], hematologic smears [10,11,14–17] or lymph node aspiration cytology [12]. We would like draw attention of the readers towards an easy AgNOR evaluation which has shown to be very useful as prognostic marker in chronic lymphoid leukemia (CLL) patients. This di...

Aim: In this study, it was aimed to examine the time and dose dependent effects of Ginseng (Panax quinquefolius) on MDA-MB-231 cell lines. Material Methods: breast cancer line used in study. cells were exposed ginseng at 37°C 5% CO2 for varying durations (24 48 hours) doses (1 2 μg/ml ginseng). At end incubation period, viability, apoptosis, cycle Argyrophilic nucleolar organizing region (AgNOR...

Using a silver staining technique, nucleolar organiser regions were identified in routinely processed paraffin sections of a range of dermal melanotic lesions. The technique shows argyrophilic NOR associated proteins (AgNORs), which are seen in nuclei as black dots. Although the nuclei of melanocarcinoma in situ, melanocarcinoma per se, and lentigo maligna contained similar numbers of AgNORs, i...

The diagnosis of uterine smooth muscle neoplasms by light microscopy is difficult. Multiple classification schemes have been proposed based on mitotic rate, nuclear atypia, and the presence or absence of necrosis. None of these classification systems has been entirely successful. This study was undertaken to evaluate the use of selected immunohistochemical and histochemical markers in different...

S AND ORAL PRESENTATIONS 1. T.Solymosi, V.Toth, M.Bodo, I.Gal. Evaluation of nucleolar organizer region-associated proteins in thyroid cytopathology. Acta Cytol 1993, 37, 622 2. T.Solymosi, I.Gal, I.Györi. Nucleolar organizer regions in colonic cytopreparations. Acta Cytol, 1993, 37, 622-623 3. I.Gal, T.Solymosi, I.Györi. Comparison of nucleolar organizer regions in cytopreparations derived fro...

AIM To evaluate the haemopoietic function of bone marrow blood forming cells in human myelodysplastic syndromes (MDS) by silver staining of nucleolar organiser regions (AgNORs). METHODS Nucleoli were investigated in bone marrow blast cells and in erythroid, granulocytic, and megakaryocytic cells from 12 haematologically healthy subjects, and from 26 patients with MDS, including 14 with refrac...