نتایج جستجو برای: agrp عضله
تعداد نتایج: 3660 فیلتر نتایج به سال:
Signaling by the corticotropin-releasing factor receptor type 1 (CRFR1) plays an important role in mediating the autonomic response to stressful challenges. Multiple hypothalamic nuclei regulate sympathetic outflow. Although CRFR1 is highly expressed in the arcuate nucleus (Arc) of the hypothalamus, the identity of these neurons and the role of CRFR1 here are presently unknown. Our studies show...
There are several lines of evidence suggesting that glucocorticoid signaling in the hypothalamus plays an important role in energy balance, and recent studies suggest that endoplasmic reticulum (ER) stress in the hypothalamus could affect signaling related to energy balance. In the present study, we examined the regulation of glucocorticoid signaling under ER stress in mouse hypothalamic organo...
A role for brain-specific homeobox factor Bsx in the control of hyperphagia and locomotory behavior.
Food intake and activity-induced thermogenesis are important components of energy balance regulation. The molecular mechanism underlying the coordination of food intake with locomotory behavior to maintain energy homeostasis is unclear. We report that the brain-specific homeobox transcription factor Bsx is required for locomotory behavior, hyperphagia, and expression of the hypothalamic neurope...
Agouti-related protein (AGRP) is a recently discovered orexigenic neuropeptide that inhibits the binding and action of alpha-melanocyte-stimulating hormone derived from proopiomelanocortin (POMC) at the melanocortin 3 receptor (MC3R) and melanocortin 4 receptor (MC4R) and has been proposed to function primarily as an endogenous melanocortin antagonist. To better understand the interplay between...
Neural circuits for essential natural behaviors are shaped by selective pressure to coordinate reliable execution of flexible goal-directed actions. However, the structural and functional organization of survival-oriented circuits is poorly understood due to exceptionally complex neuroanatomy. This is exemplified by AGRP neurons, which are a molecularly defined population that is sufficient to ...
سابقه و هدف:آگوتی وابسته به پروتئین (agrp) یک پپتید اشتهاآور موثر بر تنظیم و تعادل انرژی است که به طور عمده در هسته های کمانی هیپوتالاموس بیان می شود. هدف از پژوهش حاضر بررسی تاثیرمصرف فروکتوز بر سطح agrp، انسولین و گلوکز پلاسما پس از یک جلسه فعالیت هوازی در مردان جوان دانشگاهی بود. مواد و روشها:12دانشجوی مرد غیرورزشکار (سن 37/1±33/21 سال ، وزن 89/8±25/74 کیلوگرم، قد 05/0±76/1متر و شاخص توده ب...
هدف از این پژوهش، بررسی پاسخ پروتئین وابسته به آگوتی (agrp) به مصرف گلوکز پس از یک جلسه فعالیت هوازی در مردان غیرورزشکار بود. 12 دانشجوی مرد غیرورزشکار (سن 37/1±33/21 سال، وزن 89/8±25/74 کیلوگرم، قد 05/0±76/1 متر و شاخص تودۀ بدنی 22/2±68/23 کیلوگرم بر مترمربع) به طور تصادفی به گروههای آب و گلوکز تقسیم شدند. نمونه گیری خون در سه مرحله قبل، بلافاصله و 90 دقیقه پس از فعالیت گرفته شد. از آزمودنی ها...
Hypothalamic AMP-activated protein kinase (AMPK) has been suggested to act as a key sensing mechanism, responding to hormones and nutrients in the regulation of energy homeostasis. However, the precise neuronal populations and cellular mechanisms involved are unclear. The effects of long-term manipulation of hypothalamic AMPK on energy balance are also unknown. To directly address such issues, ...
The avian central melanocortin system is well conserved between birds and mammals in terms of the component genes, the localisation of their expression in the hypothalamic arcuate nucleus, the effects on feeding behaviour of their encoded peptides and the sensitivity of agouti-related protein (AGRP) and pro-opiomelanocortin (POMC) gene expression to changes in energy status. Our recent research...
Overexpression of agouti-related peptide (AgRP), an endogenous melanocortin (MC) 3 and 4 receptor antagonist (MC3/4-R), causes obesity. Exogenous AgRP-(83---132) increases food intake, but its duration and mode of action are unknown. We report herein that doses as low as 10 pmol can have a potent effect on food intake of rats over a 24-h period after intracerebroventricular injection. Additiona...
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