background: the present study was performed to investigate the effects of trace elements particularity se, zn and cu on tumor genesis in breast cancer. methods: the inhibitory effect of se, zn and cu, on telomerase activity was analyzed in human breast tumor tissues and breast cancer (t47d) cells. tissue specimens from 24 women with benign breast disease and 32 women with breast cancer specimen...

Primary soft tissue sarcomas of the breast constitute less than 5% of all soft tissue sarcomas and less than 1% of malignant breast cancers. The rarity of this tumor limits most studies to small retrospective case reviews and case reports. Primary breast sarcomas are locally aggressive tumors as evidenced by the high rate of local recurrence when excisional surgery is performed. A contemporary ...

Over-expression of the HER2/neu receptor occurs in 20 to 30 percent of breast tumors and is linked to poorer prognosis. The HER2/neu expression status determines whether or not patient will receive trastuzumab-based treatment. In clinical practice, over-expression of HER2/neu is routinely identified using Immunohistochemistry (IHC) or Fluorescence in Situ Hybridization (FISH), both of which are...

The TGF-β pathway plays a major role in tumor progression through regulation of epithelial and stromal cell signaling. Dysfunction of the pathway can lead to carcinoma progression and metastasis. To gain insight into the stromal role of the TGF-β pathway in breast cancer, we performed laser capture microdissection (LCM) from breast cancer patients and reduction mammoplasty patients. Microdissec...

OBJECTIVE Planning of breast radiation for patients with breast conserving surgery often relies on clinical markers such as scars. Lately, surgical clips have been used to identify the tumor location. The purpose of this study was to evaluate the geographic miss index (GMI) and the normal tissue index (NTI) for the electron boost in breast cancer treatment plans with and without surgical clips....

abstract bachground and aim: mutation analysis of mitochondrial genome and brca genes are helpful in the early diagnosis of familial breast cancers. in this study, we investigated mitochondrial common deletion and brca mutations through multiplex pcr and clinical parameters for the detection of familial breast cancers in archival breast cancer samples. methods: the multiplex pcr was conducted o...

PURPOSE To evaluate blood oxygenation level-dependent (BOLD) contrast changes in healthy breast parenchyma and breast carcinoma during administration of vasoactive gas stimuli. MATERIALS AND METHODS Magnetic resonance imaging (MRI) was performed at 3T in 19 healthy premenopausal female volunteers using a single-shot fast spin echo sequence to acquire dynamic T2 -weighted images. 2% (n = 9) an...

In recent years in vivo XRF has been found to be an effective aid to occupational health in the monitoring of concentrations of Pb in bone. One popular technique is to site an appropriate source-detector arrangement proximal to the tibial bone. Particularly popular has been use of a relatively high activity point or annular source of Cd mounted on the front of a thin-window HPGe detector. XRF e...

A computer model of X-ray mammography has been developed, which uses quasi-realistic high-resolution voxel phantoms to simulate the breast. The phantoms have 400 microm voxels and simulate the three-dimensional distributions of adipose and fibro-glandular tissues, Cooper's ligaments, ducts and skin and allow the estimation of dose to individual tissues. Calculations of the incident air kerma to...

Ultra Wideband radar systems have emerged as a good alternative for non-invasive and harmless breast cancer detection. In this paper, bistatic monostatic are proposed, which detects the deep-rooted smallest formation of tumor in breast. The source signal transmission through is seventh derivative Gaussian pulse. This pulse shaped using proposed sharp transition bandpass Finite Impulse Response ...