In India, a number of medicinal plants and their formulations are used to cure hepatic disorders in traditional systems of medicine. No systemic study has been done on protective effect of Cucumis trigonus Roxb. (Cucurbitaceae) to treat hepatic diseases. Protective action of C. trigonus fruit extracts was evaluated in this study in animal model of hepatotoxicity, which was induced by carbon tet...

Human studies have found alcoholics to have a smaller brain size than moderate drinkers; however, these studies are complicated by many uncontrollable factors, including timing and amount of alcohol use. Animal experiments, which can control many factors, have established that alcohol can cause damage to brain cells (i.e., neurons), which results in their loss of structure or function (i.e., ne...

Human studies have found alcoholics to have a smaller brain size than moderate drinkers; however, these studies are complicated by many uncontrollable factors, including timing and amount of alcohol use. Animal experiments, which can control many factors, have established that alcohol can cause damage to brain cells (i.e., neurons), which results in their loss of structure or function (i.e., ne...

BACKGROUND To date, there have been no published data on 12-month comorbidity of DSM-IV alcohol and drug use disorders in the general U.S. population. The purposes of the present study were to examine the prevalence and comorbidity of alcohol and specific drug use disorders, and to identify sociodemographic and psychopathologic correlates and treatment seeking among three groups of respondents:...

BACKGROUND Fetal Alcohol Spectrum Disorder (FASD) is associated with a range of disabilities, including physical, behavioural, and cognitive deficits. One specific area of concern in children with FASD is the use and development of speech and language. Language deficits in FASD have been linked to learning problems and social difficulties. OBJECTIVES The current study sought to examine the la...

Background Ridderinkhof and colleagues in 2002 [1] reported that moderate “acute” alcohol intake reduces the amplitude of the ‘error-related negativity, a negative deflection in the electroencephalogram associated with error commission in speeded response time tasks. Their work is however, subject to a great deal of criticism. To consider arrow flank tasks responses generally, as cognitive func...

Recent studies have linked changes in peripheral chemokine concentrations to the presence of both addictive behaviors and psychiatric disorders. The present study further explore this link by analyzing the potential association of psychiatry comorbidity with alterations in the concentrations of circulating plasma chemokine in patients of both sexes diagnosed with alcohol use disorders (AUD). To...

AIM Impaired illness insight may hamper treatment outcome in patients with alcohol-related cognitive deficits. In this study, a short questionnaire for the assessment of illness insight (eg, the Q8) was investigated in patients with Korsakoff's syndrome (KS) and in alcohol use disorder (AUD) patients with mild neurocognitive deficits. METHODS First, reliability coefficients were computed and ...

depression, anxiety and psychotic disorders, facilitating research on AUD and depression within the context of the broader field of substance-related comorbidity. Continued refinement of methods to collect and analyze real-time assessments of drinking, alcohol-related symptoms and depressed affect [13] will also be essential to advance knowledge. Interestingly, the induced-independent typology ...

In India, a number of medicinal plants and their formulations are used to cure hepatic disorders in traditional systems of medicine. No systemic study has been done on protective effect of Cucumis trigonus Roxb. (Cucurbitaceae) to treat hepatic diseases. Protective action of C. trigonus fruit extracts was evaluated in this study in animal model of hepatotoxicity, which was induced by carbon tet...