Non-alcoholic fatty liver disease, including non-alcoholic steatohepatitis (NASH), appears to be increasingly common worldwide. The aim of the study was to investigate the effects of 6-gingerol ((S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone), a bioactive ingredient of plants belonging to the Zingiberaceae family, on experimental models of NASH. In HepG2 cells, 6-gingerol (100 μmol/L) t...

UNLABELLED The present review includes translational and clinical research that characterize non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). Clinical and experimental evidence led to the recognition of the key toxic role played by lipotoxicity in the pathogenesis of NAFLD. The current understanding of lipotoxicity suggests that organ injury is initiated by th...

Non-alcoholic fatty liver had been believed to be a non-progressive benign disease. However, Ludwig et al. described some patients who exhibited progressive steatohepatitis without habitual alcohol drinking (Ludwig et al., 1980) and referred to this disease as non-alcoholic steatohepatitis (NASH). Later, NASH and non-progressive simple steatosis patients were included in the single disease enti...

Conophylline (CnP), a vinca alkaloid extracted from the leaves of the tropical plant Ervatamia microphylla, attenuates hepatic fibrosis in mice. However, little is known about whether CnP inhibits steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) in mice. A methionine-choline-deficient (MCD) diet was administered to male db/db mice as a NASH model, and CnP (1 μg/kg/d...

Non-alcoholic steatohepatitis (NASH) is a component of a wide spectrum of diseases that go from non-alcoholic fatty liver disease (NAFLD) to cirrhosis, and hepatocellular carcinoma in 40-60% of patients with NASH-related cirrhosis in a 5-7 year follow-up [1]. NASH has become one of the leading causes of liver disease in the developed world. With NAFLD believed to have doubled in the past 20 yea...

Submit Manuscript | http://medcraveonline.com Abbreviations: IM: Intestinal Metaplasia; EAC: Esophageal Adenocarcinoma; HGD: High Grade Dysplasia; LGD: Low Grade Dysplasia; GAVE: Gastric Astral Vascular Ectasia; GERD: Gastroesophageal Acid Reflux Disease; PPI: Proton Pump Inhibitor; HCC: Hepatocellular Carcinoma; ASGE: American Society of Gastrointestinal Endoscopy; BE: Barrett’s Esophagus; EGD...

MZ: Meso-Zeaxanthin; L: Lutein; RZ: RR-Zeaxanthin; AMD: Age-related Macular Degeneration; MD: Macular Degeneration; NAFL: Non-Alcoholic Fatty Liver; NASH: Nonalcoholic Steatohepatitis; DPPH: Diphenyl-2-Picrylhydrazyl; ABTS: 2, 2’-Azino-Bis (3-Ethylbenzothiazoline-6-Sulfonic acid); GST: Glutathione-S-Transferase; UDPGT: Uridine Diphosphate Glucuronyl Transferase; SGOT: Serum glutamic oxaloacetic...

Non-alcoholic fatty liver disease is the most prevalent with a global prevalence of 25%. The frequency non-alcoholic and percentage people severe are expected to rise given ongoing obesity pandemic, in diabetes, other factors. This will have significant effect on health care expenditure need for transplantation, which steatohepatitis already track overtake alcoholic as reason. characterized by ...

Objective — to establish the features of iron homeostasis in patients with steatohepatitis alcoholic and nonalcoholic etiology depending on presence dysmetobolic overload syndrome, identify probable link between ferrokinetics markers biochemical syndromes steatohepatitis, intensity endotoxicosis fibrosing reactions.
 Materials methods. The study was based clinical follow‑up 125 individuals...