BACKGROUND The D antigen is highly immunogenic, requiring only a small quantity of transfused red blood cells (RBCs) to cause alloimmunization in D- immunocompetent recipients. DEL was reported arousing alloimmunization to true Rh- patients. Molecular studies of the RHD gene have revealed that DEL individuals retain a grossly intact RHD gene or have a portion of RHD in their genomes. Avoiding i...

Depletion of leukocytes from all blood products may decrease the incidence of alloimmunization to HLA antigens present on the white cells and thus delay the onset of refractoriness to random donor platelet support. In order to test this hypothesis, 54 patients with hematologic malignancy or marrow aplasia were entered on a prospective randomized trial using cotton-wool filtration as a method of...

Transfusion therapy remains an important treatment modality for patients with sickle cell disease (SCD). Despite its therapeutic benefits, red blood cell transfusion results in the development of antibodies against disparate antigens on transfused red cells (alloimmunization) in approximately 20-50% of patients with SCD. Alloantibodies can cause delayed hemolytic transfusion reactions, which in...