BACKGROUND In this study, we investigated the effects of treatment with chronic antihypertensive drugs (clonidine, methyldopa, amlodipine, ramipril and rilmenidine) on oxidant-antioxidant parameters and toxic effects on DNA in rat uterus tissue. In addition, uterus tissues were examined histopathologically. MATERIALS AND METHODS A total of 36 albino Wistar rats were divided into the following...

We have analyzed two variants of Drosophila melanogaster (RS and RE) which lead to the dual phenotype of elevated DDC activity and increased resistance to dietary alpha-methyldopa relative to Oregon-R controls. Both phenotypes show tight genetic linkage to the dopa decarboxylase, Ddc, and l(2)amd genes (i.e., < 0.05 cM distant). We find that low (Oregon-R), medium (RS) and high (RE and Canton-S...

Peripartum seizure is a serious disease with substantial morbidity and mortality for the mother and fetus. Among various causes of such seizures, sometimes 2 causative factors can occur, simultaneously creating a dilemma in pharmacotherapeutic management. We describe a 34-weeks-pregnant woman with a history of epilepsy (receiving antiepileptic drugs) who had eclampsia and recurrent seizures in ...

Abstract A novel modified electrode based on cerium vanadate and copper tungstate (CeVO 4 -CuWO ) nanocomposite was prepared as a sensitive sensor for the methyldopa. The characterized by x-ray diffraction (XRD), energy dispersive spectroscope (EDX), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM) methods. cyclic voltammetry (CV) differential pulse (DPV) tech...

Introduction of newer hypotensive agents from time to time is a pointer to the unsolved problemof the treatment of hypertension. Severe hypertension (grades III and IV) is still a challengingproblem for the physician. In the therapeutic armamentarium of hypertension somenew drugs have disappeared faster than they were introduced because of their serious hazardsor limitations. A clinician has, t...

The region surrounding the dopa decarboxylase gene (Ddc) of Drosophila contains a cluster of genes, many of which appear to be functionally related by virtue of their effects on cuticle development and/or catecholamine metabolism. In this report we describe evidence that the Ddc gene and the closely linked alpha-methyldopa hypersensitive (amd) gene share extensive sequence homology and are the ...

The decarboxylases are involved in neurotransmitter synthesis in animals, and in pathways of secondary metabolism in plants. Different decarboxylase proteins are characterized for their different substrate specificities, but are encoded by homologous genes. We study, within a maximum-likelihood framework, the evolutionary relationships among dopa decarboxylase (Ddc), histidine decarboxylase (Hd...