The aim of the present study was to investigate the anticancer properties of five alkaloids isolated from Amaryllidaceae, including the inhibitory effect on P-glycoprotein (P-gp) and the apoptosis-inducing capacity. The tested alkaloids were evaluated for their multidrug resistance (MDR)-reversing activity on human MDR1-gene-transfected L5178 mouse lymphoma cells, using the rhodamine-123 (Rh-12...

Lycoris aurea (L' Hér.) Herb, a perennial grass species, produces a unique variety of pharmacologically active Amaryllidaceae alkaloids. However, the key enzymes and their expression pattern involved in the biosynthesis of Amaryllidaceae alkaloids (especially for galanthamine) are far from being fully understood. Quantitative real-time polymerase chain reaction (qRT-PCR), a commonly used method...

We present the results of cladistic analyses of morphology, nrDNA ITS sequences, and a combination of the two for tribe Amaryllideae of the Amaryllidaceae. The morphologically based analysis supports the recognition of Amaryllis as sister to two major clades, equivalent to Snijman and Linder's (1996, Annals of the Missouri Botanical Garden 83: 362-386) Crininae and Amaryllidinae (less Amaryllis...

The genus Allium L., Amaryllidaceae includes numerous economically important vegetables used primarily for their unique flavors. Most people recognize the main vegetable alliums, such as bulb onion and shallot (A. cepa), garlic (A. sativum), leek (A. ampeloprasum var. porrum), and chive (A. schoenoprasum). However, there are numerous cultivated vegetable alliums of more regional importance, inc...

The authors would like to acknowledge Universitat d’Alacant for the possibility of conducting this work by means a grant included in program “Becas y Contratos para la formacion de Doctores del Vicerrectorado Investigacion, FPU2010” and specific funding research stay start some cultures. Also, was partly supported R+D+I lines Spanish Ministry Environment “Ministerio Medio Ambiente Rural Marino”...

Two new Amaryllidaceae alkaloids, belonging to the mesembrine- and crinine-types, named crinsarnine (1) and sarniensinol (2), were isolated from the dried bulbs of Nerine sarniensis together with bowdensine (3), sarniensine (4), hippadine (5) and 1-O-acetyl-lycorine (6). Crinsarnine (1) and sarniensinol (2) were characterized using spectroscopic and chiroptical methods as (1S,2S,4aR,10bS)-2,7-d...

background: crinum purpurascens is a herbaceous plant belonging to the amaryllidaceae family. we aimed to evaluate the antisalmonellal properties of the leaf extracts and fractions of c. purpurascens , and the toxicity of the most active extract.   methods: three extracts and three fractions were prepared from the leaves of crinum purp urascens herb. (amaryllidaceae) and tested for their antisa...