نتایج جستجو برای: amine functionalized

تعداد نتایج: 41169  

Journal: :Organic & biomolecular chemistry 2015
Reuben Ovadia Aurélien Lebrun Ivan Barvik Jean-Jacques Vasseur Carine Baraguey Karine Alvarez

A solution phase synthesis of peptide nucleic acid monomers and dimers was developed by using microwave-promoted Ugi multicomponent reactions. A mixture of a functionalized amine, a carboxymethyl nucleobase, paraformaldehyde and an isocyanide as building blocks generates PNA monomers which are then partially deprotected and used in a second Ugi 4CC reaction, leading to PNA dimers. Conformationa...

Journal: :Physical chemistry chemical physics : PCCP 2007
Graziano Fabbrini Raffaele Riccò Enzo Menna Michele Maggini Vincenzo Amendola Mattia Garbin Massimo Villano Moreno Meneghetti

Functionalized distyrylbenzene analogs and , bearing a tris-(2-pyridylmethyl)amine-based receptor for Zn(2+), were synthesized by a Horner-Emmons-Wittig coupling reaction. It has been found that Zn(2+) complexation induces changes in the linear absorption spectrum that enhance a nonlinear sequential two-photon absorption of nanosecond pulses at 532 nm. This absorption was also found to depend o...

2015
Wei Zhang Xiao-juan Luo Li-na Niu Hong-ye Yang Cynthia K.Y. Yiu Tian-da Wang Li-qun Zhou Jing Mao Cui Huang David H. Pashley Franklin R. Tay

Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen m...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2004
Ola Blixt Steve Head Tony Mondala Christopher Scanlan Margaret E Huflejt Richard Alvarez Marian C Bryan Fabio Fazio Daniel Calarese James Stevens Nahid Razi David J Stevens John J Skehel Irma van Die Dennis R Burton Ian A Wilson Richard Cummings Nicolai Bovin Chi-Huey Wong James C Paulson

Here we describe a glycan microarray constructed by using standard robotic microarray printing technology to couple amine functionalized glycans to an amino-reactive glass slide. The array comprises 200 synthetic and natural glycan sequences representing major glycan structures of glycoproteins and glycolipids. The array has remarkable utility for profiling the specificity of a diverse range of...

Journal: :Organic & biomolecular chemistry 2012
Yan Hao Xiao-Ping Xu Tao Chen Li-Li Zhao Shun-Jun Ji

A simple and novel protocol for the efficient synthesis of a series of 8-carboxylnaphthyl functionalized pyrazolo[3,4-b]pyridine derivatives was developed through a one-pot, three-component reaction involving acenaphthylene-1,2-dione and 1H-pyrazol-5-amine in acetic acid medium. The reaction represents the first facile conversion of acenaphthenequinone to naphthoic acid via C-C bond cleavage wi...

Journal: :Chemical communications 2012
Maitane Fernández Jose L Vicario Efraím Reyes Luisa Carrillo Dolores Badía

We have developed an efficient procedure for the easy and straightforward preparation of functionalized dihydropyridazines as highly enantiopure materials by reaction of pyruvaldehyde 2-tosyl hydrazone with a variety of α,β-unsaturated aldehydes using a chiral secondary amine as catalyst. The overall process consists of a cascade reaction involving an initial aza-Michael reaction, in which the ...

Journal: :Nucleic acids research 1990
S Agrawal P C Zamecnik

The synthesis of an oligonucleotide functionalized to attach two different reporter groups at specific internucleotide linkages is described. To incorporate the amine specific reporter group the internucleotide linkage is modified to phosphoramidate (N-1-aminoalkyl) and for a thiol specific reporter group the internucleotide linkage is modified to a phosphorothioate diester. The synthetic cycle...

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