Glucagon alone, given to adrenalectomized rats, caused induction of tyrosine aminotransferase only in repeated doses. A single dose given with or 5 hours after hydrocortisone enhanced 3-fold the induction of tyrosine aminotransferase by the hydrocortisone. Glucagon did not alter the levels of tryptophan oxygenase in these situations. The simultaneous administration of actinomycin D completely i...

The synthesis of the enzyme tyrosine aminotransferase in HTC cells (an established line of rat hepatoma cells) is inducible by glucocorticoid hormones only during the latter part of G1 phase and throughout S phase in the cell generation cycle. We have earlier shown that during the first few hours of G1 phase when the enzyme cannot be induced, its synthesis is constitutive, presumably using as t...

Cells of the tyrosine aminotransferase (EC 2.6.1.5)-inducible line, HTC, were fused with those of the BRL-62 line, which contain little or no enzyme and are unresponsive to the usual steroid inducers. Histochemical examination of the resulting heterokaryons within 24 hr of the fusion showed them to have little or no enzyme and to be unresponsive to steroids. These experiments disclose that the ...

Objective: We aimed to investigate the predictive value of first-trimester aspartate aminotransferase/platelet count ratio index (APRI) and aminotransferase/alanine aminotransferase for intrahepatic cholestasis in pregnancy (ICP).
 Material Methods: The clinical data patients who admitted Obstetrics Department Umraniye Training Research Hospital, between 2015-2020 were analyzed retrospecti...

Heart tissue injury may release cardiac enzymes into the circulation and elevate serum enzyme levels (LaDue, Wroblewski, and Karmen, 1954). Many enzymes become raised, but three enzymesaspartate aminotransferase (EC 2.6.1.1), creatine kinase (EC 2.7.3.2), and lactate dehydrogenase (EC 1.1.1.27)-have proved of particular diagnostic value. In addition, determination of lactate dehydrogenase isoen...

Heart tissue injury may release cardiac enzymes into the circulation and elevate serum enzyme levels (LaDue, Wroblewski, and Karmen, 1954). Many enzymes become raised, but three enzymesaspartate aminotransferase (EC 2.6.1.1), creatine kinase (EC 2.7.3.2), and lactate dehydrogenase (EC 1.1.1.27)-have proved of particular diagnostic value. In addition, determination of lactate dehydrogenase isoen...

1. Alanine Aminotransferase (ALT) Alanine aminotransferase measurements are used in the diagnosis and treatment of certain liver diseases (e.g., viral hepatitis and cirrhosis) and heart diseases. Elevated levels of the transaminases can indicate myocardial infarction, hepatic disease, muscular dystrophy, or organ damage. Serum elevations of ALT activity are rarely observed except in parenchymal...