The purpose of this study was preparation and evaluation of sustained release matrix type ocular mini-tablets of timolol maleate, as a potential formulation for the treatment of glaucoma. Following the initial studies on timolol maleate powder, it was formulated into ocular mini-tablets. The polymers investigated in this study included cellulose derivatives (HEC, CMC, EC) and Carbopol 971P. Man...

Metribuzin is an herbicide widely used for weed control that has been identified as a groundwater pollutant. It contaminates the environment even when it is used according to the manufacturer's instructions. To reduce herbicide leaching and increase weed control, new controlled release formulations were developed by entrapping metribuzin within a sepiolite-gel-based matrix using two clay/herbic...

Both compounds have become more commonly used in dietary supplements. Stearic acid is commonly used as a binder in tablets, and it has lubricant properties. Magnesium stearate is a lubricant commonly used in tablet formulations. After achieving a homogenous blend of powdered ingredients, adding a small amount of magnesium stearate enables the powder blend particle surface to be sufficiently coa...

Active Ingredient: All Clarithromycin Formulations Clarithromycin is a semi-synthetic macrolide antibiotic obtained by substitution of a CH3O group for the hydroxyl (OH) group at position 6 of the erythromycin lactonic ring. Specifically clarithromycin is 6-O-methyl erythromycin A. The white to off-white antibiotic powder is bitter, practically odorless, essentially insoluble in water, and slig...

The aim of this project is to develop methods for scaling up roller compaction process from lab scale to pilot scale, to determine the effect of processing parameters of roller compactors at both lab scale (instrumented roller compactor at University of Birmingham, micro-pactor at Pfizer) and pilot scale (mini-pactor from Gerteis) on the attributes of dry-granulated formulations, including the ...

Most medium formulations for improving culture of entomopathogenic nematodes (EPN) based on protein sources have used enriched media like animal feed such as dried egg yolk, lactalbumin, and liver extract, among other ingredients. Most results, however, showed unstable yields and longer production time. Many of the results do not show the detailed parameters of fermentation. Soy flour, cotton s...

The delivery of inhalation-based formulations is achieved by devices that fall into three segments: nebulizers, metered dose inhalers (MDIs), and dry powder inhalers (DPIs).2 There is much discussion about which device is most appropriate, though that discussion is well beyond the scope of this article. It is of note however, that MDIs and DPIs have been shown to function equally well when pati...

China is a country that is arousing a large amount of interest as a new mega-market, as it opens itself to a market-orientated economy and expands at a remarkable rate. However, the influx of international investment, new business opportunities and advertising from overseas has seen Chinese consumers being exposed to potentially offensive advertising products and images. While some products and...

Sorghum stemborer species remains key yield limiting factor for sorghum production in the Nigerian semi-arid region. When they can afford, farmers rely almost solely on synthetic insecticides for control. Owing to the misuse and environmental and health challenges attributed to the use of synthetic insecticides, a two-year field study was carried out at the University of Maiduguri Research Farm...

The objectives of present investigations were to optimize concentration of oil, surfactant and cosurfactant by pseudoternary phase diagrams and to develop a stable formulation of self emulsifying drug delivery system (SEDDS) in order to enhance the dissolution rate of poorly soluble Irbesartan (IBS) by SEDDS. Pseudoternary phase diagrams were constructed to identify the self emulsifying region....