Background. This study sought to investigate the antidiabetic and antihypertensive mechanisms of cocoa (Theobroma cacao) bean through inhibition of α-amylase, α-glucosidase, angiotensin-1 converting enzyme, and oxidative stress. Methodology. The total phenol and flavonoid contents of the water extractable phytochemicals from the powdered cocoa bean were determined and the effects of the extract...

Diabetes mellitus is a metabolic disorder which has emerged as a global public health threat in the present century. The present oral hypoglycemic agents produce undesirable side effects and oxidative stress. Thus there is a need for a safe, cost effective and complementary therapy for Diabetes mellitus. To evaluate the Nitric oxide scavenging activity and Alpha amylase inhibitory activity of P...

Diabetes mellitus is a metabolic disorder characterized by chronic hyperglycemia and its type II is the major form of diabetes mellitus, accounting for 90% of cases worldwide. The management of the blood glucose level is a critical strategy in the control of diabetes mellitus complications. There are many and diverse therapeutic strategies in the management of Type II diabetes. The inhibition o...

Galanin inhibits pancreatic amylase secretion from mouse lobules induced by physiological concentrations of caerulein via an insulin-dependent mechanism. We aimed to determine the effect and elucidate the mechanism of action of exogenous galanin on pancreatic amylase secretion induced by supramaximal concentrations of caerulein. Amylase secretion from isolated murine pancreatic lobules was meas...

There has been an enormous interest in the development of alternative medicines for type 2 diabetes, specifically screening for phytochemicals with the ability to delay or prevent glucose absorption. The goal of the present study was to provide in vitro evidence for potential inhibition of α-glucosidase and α-amylase enzymes, followed by a confirmatory in vivo study on rats to generate a strong...

To determine the role of 1,2-diacylglycerol (1,2-DAG) and protein kinase C in pancreatic enzyme secretion, we measured the effect of various pancreatic secretagogues on the cellular mass of 1,2-DAG and amylase release in dispersed pancreatic acini from the guinea pig. In addition, we measured the effect of a recently described protein kinase C inhibitor 1-(5-isoquinolinesulfonyl)-2-methylpipera...

objective(s):ethnopharmacological field surveys demonstrated that many plants, such as gentiana olivieri, helichrysum graveolens, helichrysum plicatum ssp. plicatum, juniperus oxycedrus ssp. oxycedrus, juniperus  communis var. saxatilis, viscum album (ssp. album, ssp. austriacum), are used as traditional medicine for diabetes in different regions of anatolia. the present study was designed to e...

The Borassus flabellifer fruit which is one of the summer fruits India can be considered a promising therapeutic food as it good source bioactive compounds. aim this study was to evaluate antibacterial, anticancer and antidiabetic activity locally available aqueous freeze-dried seed powder extract flabellifer. Antibacterial evaluated using agar well diffusion assay against gram-positive bacteri...

Alpha amylases cleave the starch like molecules and led to increase in blood sugar level diabetic patients then order manage it inhibition action is carried out by their inhibitors. The α-amylase inhibitors catalyses process of endo-hydrolysis α (1→ 4) glycosidic linkage present which ultimately decrease hydrolysis process. It also affects carbohydrate absorption intestine. In 1945, first alpha...

Homalium zeylanicum (Gardner) Benth. (Flacourtiaceae) is a medicinal plant useful in controlling rheumatism, inflammation and diabetes. The objective of this work evaluates in vitro antioxidant, antidiabetic, and antiinflammatory properties of hydroalcohol extract of bark of H. zeylanicum (HAHZ). It also describes isolation and structure determination of lucidenic acid A, which is the first rep...