Hexanucleotide (GGGGCC) repeat expansion in C9ORF72 (HRE) causes frontotemporal lobar degeneration, frontotemporal dementia-amyotrophic lateral sclerosis, and amyotrophic lateral sclerosis. HRE was also seen in the genomes of patients suffering from several other degenerative diseases. However, whether it is present in the treatment-resistant schizophrenia patients remains unknown. Genotyping 3...

When there are many people who don't need to expect something more than the benefits to take, we will suggest you to have willing to reach all benefits. Be sure and surely do to take this amyotrophic lateral sclerosis therapeutic psychological and research aspects that gives the best reasons to read. When you really need to get the reason why, this amyotrophic lateral sclerosis therapeutic psyc...

The cover image is based on the Original Article Neuromuscular junction denervation and terminal Schwann cell loss in hTDP-43 overexpression mouse model of amyotrophic lateral sclerosis by Abrar Alhindi et al., https://doi.org/10.1111/nan.12925. Image Credit: Helena Chaytow.

We report a 60-year-old case diagnosed as the amyotrophic lateral sclerosis with patulous eustachian tube (ET). To our knowledge, this is the first case report of the amyotrophic lateral sclerosis complicating patulous ET in the literature, demonstrating the movement of the tympanic membrane, the pharyngeal orifice of the ET and abnormal movement of the uvula because of paralysis of the soft pa...

This study compares speaking rate in spontaneous speech between dysarthric and healthy speakers. Since dysarthria involves heterogeneous pathologies, two types of dysarthria (i.e. Parkinson’s disease and amyotrophic lateral sclerosis) have been distinguished. We hypothesize that temporal organisation of speech may be different between healthy and dysarthric speakers, but also between both patho...

OBJECTIVE To discuss the epidemiology, pathogenesis, diagnosis, expected course, prognosis, and treatment of amyotrophic lateral sclerosis (ALS), a degenerative disorder of the nervous system associated with progressive weakness. QUALITY OF EVIDENCE PubMed and the Cochrane Database of Systematic Reviews were searched using the MeSH headings "amyotrophic lateral sclerosis," "therapy," "epidemi...

INTRODUCTION Amyotrophic lateral sclerosis (the most common form of motor neuron disease) is a progressive and devastating disease involving both lower and upper motor neurons, typically following a relentless path towards death. Given the gravity of this diagnosis, all efforts must be made by the clinician to exclude alternative and more treatable entities. Frequent serology testing involves s...

Please cite this article as: Hans-Peter Müller, Martin Gorges, Rebecca Kassubek, Johannes Dorst, Albert C. Ludolph, Jan Kassubek , Identical patterns of cortico-efferent tract involvement in primary lateral sclerosis and amyotrophic lateral sclerosis: A tract of interest-based MRI study. The address for the corresponding author was captured as affiliation for all authors. Please check if approp...