proteins, termed anchorage independence of growth, correlates closely with tumorigenicity in animal models (14). This property of cancer cells presumably reflects the tendency of tumor cells to survive and grow in inappropriate locations in vivo. Such incorrect localization, as occurs in invasion and metastasis, is the characteristic that distinguishes malignant from benign tumors (31). Great p...

BACKGROUND The traditional Herbst appliance induces mandibular incisor proclination independent of the anchorage system used. The dental effects of the Herbst appliance as an element of a completely customized lingual orthodontic (LO) appliance (Incognito, 3 M) has not been analyzed yet and the aim of this paper was to measure the effect of mandibular incisor proclination using this Herbst-LO d...

281 P loss of the mandibular second premolars and first molars due to caries or periodontal disease can lead to mesioinclination of the second molars. Various orthodontic methods have been used to upright the lower molars for prosthetic rehabilitation,1-8 but these generally involve molar extrusion and reciprocal movement of the anchorage unit.9 Conventional flexible alloy or rectangular stainl...

In orthodontics, anchorage is a prerequisite for the application of therapeutic forces and can limit their successful use. According to the intended treatment goals, desired tooth movements should, therefore, be maximized and undesirable effects minimized. But additional anchorage such as extraand intraoral forces are visible and hence compliance dependent and are associated with the risk of un...

About the Community Anchorage is a combined city-county government that covers Alaska's largest and most important metropolitan area. The combined municipality covers almost 2,000 square miles and has a population of over 280,000. Some 220,000 people live in the " Anchorage Bowl " – the urban area on the Anchorage peninsula that is cut off from the rest of the municipality by geography, militar...

The mitochondrial Bit1 (Bcl-2 inhibitor of transcription 1) protein is a part of an apoptotic pathway that is uniquely regulated by integrin-mediated attachment. As an anoikis effector, Bit1 is released into the cytoplasm following loss of cell attachment and induces a caspase-independent form of apoptosis. Considering that anoikis resistance is a critical determinant of transformation, we hypo...

The cyclin-dependent kinase inhibitor p21WAF1 has been characterized as an important effector of the tumor suppressor p53 and has been linked to various growth-regulatory processes. To identify a potential role of p21 in anchorage-dependent growth control, we analyzed a pair of HCT116 human colon carcinoma cell lines that differed only in their p21 status. We found that during suspension cultur...

In the present study, we investigated the effects of several selective protein kinase C (PKC) inhibitors (Gö6976, Gö6983, bisindolylmaleimide I, and rottlerin) in combination with conventional anticancer drugs on apoptosis and long-term anchorage-independent growth of both parental and Bcl-2-overexpressing mammary adenocarcinoma MTLn3 cells. In normal MTLn3 cells, doxorubicin- and etoposide-ind...