OBJECTIVES/HYPOTHESIS The purpose of this study was to evaluate the Ras GTPase (Ras) to extracellular signal-regulated kinase (ERK) pathway in vestibular schwannoma (VS) cell cultures and patient excised schwannoma tumors. Mitogen-activated protein kinase kinase (MEK) inhibitor CI-1040 (PD184352) was utilized to evaluate the effect of specific MEK inhibition on benign schwannoma cell culture pr...

schwannoma is a solitary, slow growing,  benign tumour of the peripheral  nerve sheath, and it is most common locations are the head, neck, the flexor surfaces of the extremities, retroperitoneal and posterior mediastinium. external female genital organs are the least common location site of the schwannoma. only a few cases of vulvar schwannoma have been reported.we report 65 year- old woman pr...

Magnetic Resonance Imaging (MRI) has been the primary imaging modality and has revolutionized the imaging of brain tumors. MRI can display accurate multi planer imaging without interfering of adjacent structures specially for posterior fossa mass lesion. MRI is the imaging modality of choice for cerebollo-pontine (CP) angle Schwannoma. The study was performed to determine, the diagnostic accura...

Introduction: Presence of vestibular schwannoma and a simultaneous glomus jugulare tumor is an extremely rare event. There is only one case report regarding the incidence of a contralateral vestibular schwannoma, along with a glomus jugulare tumor. Herein, we present the second case with a contralateral tumor.   Case Report: A 69-year-old woman presented with a long hist...

Schwannoma is a benign tumor that originates from Schwann cells of the peripheral nerve. Occurring as a common tumor in the head and neck region, its intraoral presentation is rare which accounts for only 1%. They are solitary, slow-growing, smooth-surfaced, usually asymptomatic, and encapsulated tumor. This paper comprises two case reports, both of which presented with an intraoral soft tissue...

Hybrid benign peripheral nerve sheath tumors are rare tumors exhibiting areas of more than one neural neoplasm such as schwannoma/neurofibroma, neurofibroma/perineurioma, or schwannoma/perineurioma. These tumors usually arise in the skin of the extremities and trunk, and less commonly affect extracutaneous sites. Here we report two cases of these tumors exhibiting hybrid features of schwannoma/...

Benign epithelioid schwannoma is a very rare variant of schwannoma, that can pose a diagnostic challenge. The reported cases were predominantly located in dermal/subcutaneous tissue. Although conventional schwannoma occurring in the posterior mediastinum was common, to our knowledge, no mediastinal benign epithelioid schwannoma was reported in English literature. Herein, we presented a case of ...