In some cellular systems, particularly neurons, amyloid precursor-like protein 2 (APLP2), and its highly homologous family member amyloid precursor protein (APP), have been linked to cellular growth. APLP2 and APP undergo regulated intramembrane proteolysis to produce C-terminal fragments. In this study, we found comprehensive expression of APLP2 C-terminal fragments in a panel of pancreatic ca...

@article{KautEA12, author = {Michal Kaut and Kjetil T. Midthun and Adrian S. Werner and Asgeir Tomasgard and Lars Hellemo and Marte Fodstad}, title = {Multi-horizon stochastic programming}, journal = {Computational Management Science}, year = {2014}, volume = {11}, number = {1--2}, pages = {179--193}, note = {Special Issue: Computational Techniques in Management Science}, doi = {10.1007/s10287-...

The author acknowledge support from National Institute of Health Research Grants MH55687 and AG15685. Marc Howard is now at the Department of Psychology, Boston University, 64 Cunningham Street, Boston, MA 02215. Address correspondence and reprint requests to Michael J. Kahana, Volen Center for Complex Systems, Brandeis University, MS 013, Waltham, MA 02254. E-mail: [email protected]. Marc W....

From the Diabetes Research Centre,WHO Collaborating Centre for Research, Education & Training in Diabetes,Chennai-India Correspondence to :Dr. Vijay Viswanathan, Diabetes Research Centre,WHO Collaborating Centre for Research, Education & Training in diabetes 5, Main Road, Royapuram Chennai 600 013.India Efficacy of Glycated Albumin (GA) in Comparison with Glycated Haemoglobin (HbA1c) in Type 2 ...

In this ISR the Proposal Instructions for the NICMOS Science Instrument are described. This report discusses the possible SI configurations, modes, and most of the optional parameters. The optional parameters which support the creation and association of patterns of exposures are discussed in a companion ISR (NICMOS-013).

BACKGROUND AND PURPOSE Sphingosine 1-phosphate (S1P) selectively and potently constricts isolated cerebral arteries, but this response has not been pharmacologically characterized. EXPERIMENTAL APPROACH The receptor subtype(s) involved in S1P-induced cerebrovascular constriction were characterized using genetic (S1P(2) and S1P(3) receptor null mice) and pharmacological tools (phospho-FTY720, ...

Head and neck squamous cell carcinoma (HNSCC) development is closely associated with inflammation. Cyclooxygenase-2 (COX-2) is an important mediator of inflammation. Therefore, celecoxib, a selective inhibitor of COX-2, was hailed as a promising chemopreventive agent for HNSCC. Dose-dependent cardiac toxicity limits long-term use of celecoxib, but it seems likely that this may be diminished by ...

The Poisson sigma model is a widely studied two-dimensional topological field theory. This note shows that boundary conditions for the Poisson sigma model are related to coisotropic submanifolds (a result announced in [math.QA/0309180]) and that the corresponding reduced phase space is a (possibly singular) dual pair between the reduced spaces of the given two coisotropic submanifolds. In addit...

During the 2020-2022 COVID-19 global pandemic many researchers had to adopt or switch online testing, which emphasized need for ensuring measurement equivalence across different administration methods. The aim of this study was determine whether gender stereotype measure (VGSA scale; Vocational Gender Stereotype Attitudes Scale) is equivalent in two computer-based modes: supervised in-class and...