Exo-polysaccharides like dextran produced by Weissella sp. have a wide range of applications in the food, pharmaceutical and other industries. This biopolymer and its derivatives like iron dextran, clinical dextran are rapidly emerging as a new and industrially important products. Dextran a polymer of glucose is produced using sucrose rich media with nitrogen source. It also requires efficient ...

The erythropoietic effects of sustained intraperitoneal (i.p.) administration of CoCl2 and NiCl2 were compared with the effects of a single intrarenal (i.r.) injection of alpha Ni3S2 in female Fischer-344 rats. Infusion of NiCl2 by osmotic minipumps (0.85 mg Ni per day, i.p., for 24 days; total dose = 20 mg Ni per rat) did not alter the blood hematocrit or reticulocyte count during six weeks of...

Cobalt inhibits prolyl hydroxylases, leading to the accumulation of hypoxia-inducible factor-1α (HIF-1α) and a concomitant increase in the transcriptional activity of HIF-1. Therefore, cobalt has been under development as a drug for activating HIF-1 under some disease conditions. However, it has been shown that ischemic conditions resulted in the loss of copper, and the activation of HIF-1 woul...

An ionophore-doped sensing membrane phosphate (PO4) microsensor based on bis(dibromophenylstannyl)methane (Bis microsensor) is described. The Bis microsensor showed a Nernstian response. The response of the Bis microsensor was log-linear down to a monohydrogen phosphate ion (HPO42-) concentration of 0.5 μM (corresponding to 1.0 μM of orthophosphate at pH 7.2), whereas the detection limit of PO4...

A highly effective 6-endo dig cyclisation of o-alkynylaldimines to 1,2-dihydroisoquinolines has been described via direct and nitro Mannich condensation using inexpensive and readily available cobalt chloride as catalyst. This strategy provides an effective procedure for the synthesis of substituted 1,2-dihydroisoquinolines derivatives in moderate to high yields. An addition of pronucleophiles,...

Address for correspondence: Krzysztof Gomułka MD, PhD, Department of Internal Medicine and Allergology, Wroclaw Medical University, 66 Marii Curie-Skłodowskiej St, 50-369 Wroclaw, Poland, phone: +48 71 784 25 28, e-mail: [email protected] Received: 2.11.2015, accepted: 4.10.2016. Systemic contact dermatitis caused by cobalt chloride and palladium in a 26-year-old woman with allergic type I reactio...