repeat and serum testosterone in the risk of Alzheimer’s disease in men We recently reported that the glutamine (CAG) repeat polymorphism of exon 1 of the androgen receptor was associated with Alzheimer’s disease in men from the Oxford region. If this androgen receptor polymorphism indeed affects Alzheimer’s disease risk rather than being in linkage disequilibrium with the true risk factor, the...

Mutations in the androgen receptor gene in 46,XY individuals can be associated with the androgen insensitivity syndrome, of which the phenotype can vary from a female phenotype to an undervirilized or infertile male phenotype. We have studied the androgen receptor gene of androgen insensitivity patients to get information about amino acid residues or regions involved in DNA binding and transcri...

Male sex steroids (androgens) sculpture the human embryo resulting in development of the male internal and external genitalia. At puberty, a surge of androgens leads to the initiation of spermatogenesis and growth of accessory sex organs, including the prostate gland. Sperm production is highly dependent on androgens (Zirkin et al., 1989) and it has long been suspected that suboptimal androgen ...

Spinal and bulbar muscular atrophy (Kennedy disease) is an X-linked, adult-onset motor neuron disease characterized by slow, progressive weakness of the extremity muscles with CAG triplet repeat expansion in androgen receptor gene. Hirayama (HD) juvenile onset asymmetric amyotrophy hand most common males Asia. We report a patient atypical Kennedy presenting typical HD.

Chemopreventive and potential therapeutic effects of soy isoflavones have been shown to be effective in numerous preclinical studies as well as clinical studies in prostate cancer. Although the inhibition of androgen receptor signaling has been supposed as one mechanism underlying their effects, the precise mechanism of androgen receptor inhibition remains unclear. Thus, this study aimed to cla...

Arginine vasopressin-immunoreactive (AVP-ir) neurons in the bed nucleus of stria terminalis (BST) and medial amygdaloid nucleus are very responsive to gonadal hormones. After gonadectomy, these neurons lose their AVP immunoreactivity and stop expressing AVP mRNA. Testosterone treatment reverses these changes, acting via androgen as well as estrogen receptor-mediated mechanisms. Although AVP-ir ...

This study was carried out to determine the mechanisms associated with loss of androgen dependency and disease progression in prostate cancer. We investigated the role of the androgen receptor and its relationship to other signal transduction proteins. A hormone-refractory prostate cancer cell line [high-passage LNCaP (HP-LNCaP)] was established in vitro. Cells were treated with inhibitors of m...

The aryl hydrocarbon receptor is a member of the basic-helix-loop-helix family of transcription factors. AhR mediates the biochemical and toxic effects of a number of polyaromatic hydrocarbons such as 2,3,7,8,-tetrachloro-dibenzo-p-dioxin (TCDD). AhR is widely known for regulating the transcription of drug metabolizing enzymes involved in the xenobiotic metabolism of carcinogens and therapeutic...

Purpose: Androgen receptor abundance and androgen receptor–regulated gene exAuth Repr and L Com Medi Rosw Buffa Dep Atlan Rece 12/8/ Gran HD-1 State 009 a throu Coop ww pression in castration-recurrent prostate cancer are indicative of androgen receptor activation in the absence of testicular androgen. Androgen receptor transactivation of target genes in castration-recurrent prostate cancer occ...