A range of androgen conjugates with non-conventional platinum(II) complexes have been synthesised with the aim of targeting tumour cells since many display elevated levels of the androgen receptor. The androgenic platinum conjugates are delivered into selected cells with improved efficiency (when compared to their non-steroidal analogues). The act of conjugating an androgen to a platinum(II) co...

We report a 42-year-old male amateur body builder and user of anabolic androgenic steroids, who developed ARDS, acute kidney injury, and refractory supraventricular tachycardia. He required extracorporeal membrane oxygenation, continuous veno-venous hemodialysis, and catheter ablation. We believe that long-term anabolic androgenic steroid abuse predisposed the patient to multiple organ dysfunct...

in order to determine the occurrence of endometriosis in patients with uterine myoma and in those with polycystic ovarian disease (pcod) compared to controls, 540 infertile patients were first divided into two age groups of 20-29 and 30-39. then each group was subdivided to patients with 1) uterine myoma, 2) pcod, and 3) no uterine myoma or pcod (control subgroup). the occurrence of endometrios...

BACKGROUND As oral contraceptives (OCs) suppress anti-Müllerian hormone (AMH), and hormonal contraceptives (HCs), likely, suppress functional ovarian reserve, this study was initiated to determine whether HC affect oocyte yields. METHODS We investigated in a retrospective cohort study 43 oocyte donors in 71 in vitro fertilization (IVF) cycles, evaluating anti-Müllerian hormone (AMH) and oocyt...

Estrogenic and androgenic activities of wastewater were determined during treatment in five wastewater treatment works (WWTWs) in the Untied Kingdom. With one exception, both estrogenic and androgenic activities decreased markedly as wastewater progressed through the plants; removal rates were generally 70% or higher, sometimes reaching 100%. Most of the reduction in activity occurred during se...

Introduction: The use of anabolic androgenic steroids is particularly common in regular gyms and fitness centres participants. AAS are usually synthetic derivatives testosterone with effect. However, many people, including users, do not realize how side effects they can cause.The aim the study: study was to assess if people who regularly attend gym aware using by empirical research based on ano...

Svensson, J. 2016. Progestagenic Aquatic Contaminants Act as Potent Androgens in Fish. Experimental Studies in Three-spined Stickleback and Zebrafish. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1379. 45 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-9587-9. The extensive use of pharmaceuticals and their poor removal by waste...

PATIENTS WITH adreno-cortmal hyperfunctaon-are not frequently presented to anaesthetists. The proper anaesthetac management for adrenalectomy m these cases reqmres a basic understanchng of the physlopathology of the synch'omes caused by hyperfunetlon of the adrenal cortex. The adrenal cortex secretes three types of sterold hormones, file glucocorticolds, and the mmeralo-corticolds and hormones ...

Sex hormones play an important role in adipose tissue metabolism by activating specific receptors that alter several steps of the lipolytic and lipogenic signal cascade in depot- and sex-dependent manners. However, studies focusing on steroid receptor status in adipose tissue are scarce. In the present study, we analyzed steroid content [testosterone (T), 17beta-estradiol (17beta-E2), and proge...