The tumor microenvironment (TME) is an intricate ecosystem that actively involved in various stages of cancer occurrence and development. Some characteristics biological behavior, such as proliferation, migration, invasion, inhibition apoptosis, immune escape, angiogenesis, metabolic reprogramming, are affected by TME. Studies have shown non-coding RNAs, especially long-chain RNAs microRNAs can...

Cancer is a group of diseases with significant morbidity and mortality. In cancer cells, where energy requirements are exceptionally high, angiogenesis, which the sprouting new blood vessels from pre-existing ones, an important process for tumour survival progression. Hence, extensive research in recent years focuses on discovery anticancer drugs that target angiogenesis. Several methodologies ...

A nanoparticle-based formulation of sorafenib (NP-sfb) significantly inhibited hepatocellular carcinoma by suppressing angiogenesis and promoting cytotoxic T lymphocyte infiltration.

Colorectal cancer is one of the major public health issues worldwide due to its high mortality and morbidity. Angiogenesis fundamental step tumors transition from dormant malignant state it recognized as hallmarks cancer. High mobility group AT-hook 2 encodes a small non-histone chromatinassociated protein that can modulate transcription by altering chromatin architecture. Currently mechanism w...

Tumor suppressor gene p53 and its aggregate have been found to be involved in many angiogenesis-related pathways. We explored the possible aggregation formation mechanisms commonly occur after ischemic stroke, such as hypoxia presence of reactive oxygen species (ROS). The angiogenic pathways involving mainly nucleus or cytoplasm, with one exception that occurs mitochondria. Considering high mit...

Plaque angiogenesis promotes the growth of atheromas, but the functions of plaque capillaries are not fully determined. Neovascularization may act as a conduit for the entry of leukocytes into sites of chronic inflammation. We observe vasa vasorum density correlates highly with the extent of inflammatory cells, not the size of atheromas in apolipoprotein E-deficient mice. We show atheroscleroti...

The angiogenesis activity was involved in many physiological and pathological conditions. The research on angiogenesis activity was increased and many new methods are come for the evaluation of the angiogenesis activity. Previously Robert Auerbach et al., described the methods used for the evaluation of angiogenesis activity. We added some more techniques to that which are currently used for th...