Angioid streaks (AS) are hereditary eye conditions caused by breaks in the elastic layer of Bruch's membrane. Patients with AS are also frequently affected with pseudoxanthoma elasticum (PXE). The locus of PXE has been reported to exist in chromosome 16p13.1, and the ABCC6 gene in this locus has been identified as the causal gene of PXE. In this study we investigated the association of the ABCC...

The in vitro growth and morphogenesis of mouse embryos from early primitive-streak stage to early-somite stage is described. The embryo culture method employs a static culture system, a conventional chemically defined medium (Dulbecco's modified Eagle's medium), supplemented with additional glucose, glutamine and suitably prepared serum. The method of serum preparation is important for successf...

We evaluated STREAK and the univariate signal detection model of Remember/Know (RK) judgments in terms of their ability to fit empirical data and produce psychologically meaningful parameter estimates. Participants studied pairs of words and completed item recognition tests with RK judgments as well as associative recognition tests. Fits to the RK data showed that the univariate model provided ...

Fibronectin was localized using peroxidase and biotin-avidin-ferritin techniques in developmental stages of the chick embryo from laying to primitive streak formation. The primary location of fibronectin at all stages examined was the basal lamina of the epiblast and its associated extracellular material. The remaining tissues showed little or no immunochemical deposit. At the primitive streak ...