Angiotensin-I converting enzyme (ACE), a two-domain dipeptidylcarboxypeptidase, is a key regulator of blood pressure as a result of its critical role in the renin-angiotensin-aldosterone and kallikrein-kinin systems. Hence it is an important drug target in the treatment of cardiovascular diseases. ACE is primarily known for its ability to cleave angiotensin I (Ang I) to the vasoactive octapepti...

BACKGROUND Angiotensin converting enzyme inhibitors (ACE inhibitors) reduce peripheral vascular resistance via blockage of angiotensin converting enzyme (ACE). ACE inhibitors are commonly used to treat congestive heart failure and high blood pressure, but other effects have been reported. In this study, we explored the association between ACE inhibitor therapy and the prevalence of comorbid con...

The variants of angiotensin converting enzyme (ACE) and matrix metalloproteinases (MMPs) genes might be involved in the pathogenesis of end stage renal disease (ESRD) and hypertension. We studied the ACE insertion/deletion (I/D) and MMP-7 A-181G variants in 99 unrelated ESRD patients and 117 individuals without renal complications from Western Iran with Kurdish ethnic background. The frequency ...

although primary chronic hypertension (htn) is increasingly common in adolescence, secondary forms of htn are more common among children. primary htn is associated with being overweight and/or a positive family history of htn. carotid intima-media thickness, a known risk factor for atherosclerosis is frequent in both adults and children with htn and other associated cardiovascular (cv) risk fac...

I mmunoglobulin A nephropathy (IgAN) is the most prevalent form of primary glomerulonephritis and one of the principal causes of end stage renal disease (ESRD) throughout the world. 2 It is a complex disease, in which familial clustering suggests an inherited genetic predisposition. The disease has a variable clinical course, and one third of patients with IgAN progress to ESRD within 10–20 yea...

Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I (Ang I) to angiotensin II (Ang II). ACE also cleaves the terminal dipeptide of vasodilating hormone bradykinin (a nonapeptide) to inactivate this hormone. Therefore, inhibition of ACE is generally used as one of the methods for the treatment of hypertension. 'Oxidative stress' is another disease state caused by an imb...

angiotensin-converting enzyme (ace) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. the present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (stz)-diabetic rats treated for 4 weeks with nitro-l-arginine-methyl ester (l-nam...

Background: Use of angiotensin-converting enzyme inhibitors (ACEIs)was associated with increased risk lung cancer in a cohort study from the United Kingdom. We aimed to replicate these findings Danish population. Methods: conducted nested case-control using data 4 national health and administrative registries. New users ACEIs or angiotensin II receptor blockers Denmark January 1, 2000 were foll...

Hypertension is a serious risk factor for various diseases. Therefore, lowering and preventing high blood pressure significant issue. Blockage of the renin-angiotensin-aldosterone system (RAAS), which controls pressure, important to reduce consequently symptoms heart failure. This blockage can be carried out by angiotensin-converting enzyme (ACE) angiotensin II receptor blockers (ARBs). The phe...