Eicosanoids constitute a large family of biologically active lipid mediators that are produced by two enzyme classes, cyclooxygenases (COX-1 and COX-2) and lipoxygenases (5-LO, 12-LO, and 15-LO). Increasing evidence suggests that in addition to a variety of epithelial malignancies, the two most common types of human brain tumour, gliomas and meningiomas, aberrantly overexpress eicosanoid produc...

Low-grade oncocytic tumour (LOT) of the kidney is one emerging entities included in recently published Fifth Edition WHO classification Tumours.1 It shows overlapping morphological features with oncocytoma and chromophobe renal cell carcinoma but has unique KIT negative Keratin (KRT) 7 diffuse positive immunophenotype. Herein, we describe clinical, morphological, immunohistochemical findings tw...

BACKGROUND Bulky endobronchial tumours in patients with lung cancer are difficult to treat. Brachytherapy and photodynamic therapy (PDT) are variably effective, and the combination of these treatments is not often recommended. However, cell culture studies and animal studies indicate a possible synergistic effect of combining PDT with ionising radiation. We assessed the safety and effectiveness...

N eurofibromatosis 2 (NF2) is an autosomal dominant disease that is caused by inactivating mutations of the NF2 tumour suppressor gene. 2 Multiple central and peripheral nervous system tumours and ocular abnormalities are common in NF2; bilateral vestibular schwannomas are pathognomonic for the disease. Genotype-phenotype correlations are well established for NF2 associated tumours. In general,...

INTRODUCTION Autoimmune chronic atrophic gastritis (CAG) causes hypochlorhydria and hypergastrinaemia, which can lead to enterochromaffin-like (ECL) cell hyperplasia and gastric neuroendocrine tumours (type 1 gastric NETs). Most behave indolently, but some larger tumours metastasise. Antrectomy, which removes the source of the hypergastrinaemia, usually causes tumour regression. Non-clinical an...

Muscle-invasive forms of urothelial carcinomas are responsible for most mortality in bladder cancer. Finding new treatments for invasive bladder tumours requires adequate animal models to decipher the mechanisms of progression, in particular the way tumours interact with their microenvironment. Herein, using the murine bladder tumour cell line MB49 and its more aggressive variant MB49-I, we dem...

We evaluated the possible induction of a systemic immune response to increase anti-tumour activity by the re-implantation of destructive tumour tissue treated by liquid nitrogen in a murine osteosarcoma (LM8) model. The tumours were randomised to treatment by excision alone or by cryotreatment after excision. Tissue from the tumour was frozen in liquid nitrogen, thawed in distilled water and th...

GASTRO-INTESTINAL STROMAL-TUMOURs (GASTRO-INTESTINAL STROMAL-TUMOURs) are tumours of the gut found mostly in stomach and small intestine. The complications Gastrointestinal (GI) bleeding, obstruction, pain rarely perforation. We reporting an abnormal presentation STROMAL-TUMOURS presenting as acute abdomen with Right Iliac Fossa (RIF) mass 57-year-old male. Contrast Enhanced Computed Tomography...

Abstract AIMS With diminishing returns and common clinical failure rates from traditional preclinical animal-based drug discovery strategies, emphasis is being placed on alternative platforms, such as ex vivo approaches. Such approaches represent a departure both models more clinical-based strategies aim to address intra/inter-patient variability at an earlier stage of discovery. Additionally, ...

Since the first clear demonstration of the existence of 'specific' antigens in experimental tumours (Gross, 1943; Foley, 1953), the extensive use of syngeneic animals has resulted in the identification of tumour-associated or characteristic macromolecules ('antigens') in association with spontaneously occurring or experimentally induced tumours (Old and Boyse, 1964; Baldwin, 1970; Stonehill and...