OBJECTIVE To determine the safety and efficacy of a new gel formulation of podofilox in the treatment of anogenital warts. DESIGN Double-blind, randomized, multicenter, vehicle-controlled investigation. SETTING Private dermatology practices, university clinics (dermatology, gynecology, and infectious diseases), and contract research organizations. PATIENTS Three hundred twenty-six patient...

The insecticide 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) is still used for disease control in some areas, resulting in high levels of human exposure. The main degradation product of DDT is 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE), an antiandrogen. In animal experiments, in utero exposure to DDE decreases anogenital distance in male offspring. In these models, anogenital dis...

OBJECTIVE To assess whether anogenital warts, present or past, are an indication for women to be referred for colposcopy. DESIGN A case control study comparing patients with and without a history of anogenital warts. SETTING A department of genitourinary medicine in West London. PATIENTS 468 patients examined by colposcopy between January 1985 and December 1987 of whom 147 (31%) had abnor...

verrucous carcinoma is a unique clinical and pathological entity which has been recognised in the recent years. it is a variant of well-differentiated squamous cell carcinoma which may occur in the larynx; other anatomic locations such as: the oral cavity, anogenital region, and skin may be involved. it accounts for 1-2% of all laryngeal cancers. the clinical, histopathological and biologic fea...

background: several regimens of therapy were recommended for the treatment of genital wart with different efficacies. the purpose of this study was to compare the efficacy of podophylin 20% versus trichloroacetic acid 30% in the treatment of genital wart.methods: this randomized clinical study was conducted on 120 cases with genital wart. they randomly received podophylin 20% or trichloroacetic...

Condyloma acuminata are genital or perianal warts caused mainly by human papillomavirus (HPV) types 6 and 11. In HIV-positive patients and in men who have sex with men (MSM), the prevalence of anal HPV infection is particularly high (45-95%) (1). Current therapies for condylorna acuminata include surgical excision and ablation by cryotherapy, electrocautery, or lasers. Imiquimod, a topical immu...

Male rat pups required more anogenital stimulation before they began to urinate than did their sisters and males produced more urine than their female sibs during a fixed period of anogenital stimulation. These findings are interpreted as consistent with the view that neonatal mammals can manipulate the behavior of their dams.

We report the characterization of three novel human papillomavirus (HPV) types of the genus Gammapapillomavirus. HPV175 and HPV180 were isolated from a condyloma. HPV178 was isolated from healthy skin adjacent to an actinic keratosis.