Human bone-marrow mesenchymal stem cells have an important role in the repair of musculoskeletal tissues by migrating from the bone marrow into the injured site and undergoing differentiation. We investigated the use of autologous human serum as a substitute for fetal bovine serum in the ex vivo expansion medium to avoid the transmission of dangerous transfectants during clinical reconstruction...

In order to combine the effects of bone repair and eradication of infection, with both Gram-positive and Gram-negative pathogens, the behaviour of a compound of bone graft and antibiotics was investigated. Samples of human and bovine bone, cancellous and cortical, were processed and incubated with vancomycin and tobramycin, respectively. The compound was placed in 5% human albumin and the surro...

Twenty surgically treated cases of fracture dislocation of the cervical spine are presented. All patients had hyperfelxion injuries with associated rupture of the intervertebral disc. All patients were operated on through an anterior surgical approach. Ten consecutive patientas had interbody fusion with autogenous bone and ten consecutive patients were fused anteriorly with bovine (Kiel) bone. ...

If bone adapts to maintain constant strains and if on-axis yield strains in trabecular bone are independent of apparent density, adaptive remodeling in trabecular bone should maintain a constant safety factor (yield strain/functional strain) during habitual loading. To test the hypothesis that yield strains are indeed independent of density, compressive (n = 22) and tensile (n = 22) yield strai...

Bone defects resulting from trauma, surgery, congenital malformations, and other factors are among the most common health problems nowadays. Although current strategies such as autografts allografts recognized successful treatments for stimulating bone regeneration, limitations graft source complications still exist. SmartBone® is a xeno-hybrid (made bovine matrix, poly(L-lactic-co-?-caprolacto...

PURPOSE This observational study examined the resorptive behavior of normal neonatal rabbit osteoclasts grown on slices of bovine cortical bone as compared to samples of commercially available bone substitute biomaterials. It also examined the surface characteristics of these materials. MATERIALS AND METHODS The 11 materials tested fell into 3 groups: (1) bone-derived, including freeze-dried ...

Finite element modelling of the spinal unit is a promising preclinical tool to assess biomechanical outcome emerging interventions. Currently, most models are calibrated and validated against range motion rarely directly soft-tissue deformation. The aim this contribution was develop an in vitro methodology measure disc bulge ability different specimen-specific approaches predict bulge. Bovine b...

PURPOSE To carry out a radiological and histomorphometric evaluation of bone response to two xenografts of animal origin, one porcine, and the other bovine, inserted in rabbits' tibiae. MATERIAL AND METHODS Twenty New Zealand rabbits weighing 3900-4500 g were used. Twenty bovine bone grafts (Endobon) in granulated form of 500-1000 μm granulometry were inserted in the proximal metaphyseal area...

PURPOSE This study was performed to evaluate the periodontal wound healing effect of particulate equine bone mineral on canine alveolar bone defects. METHODS Twelve adult male beagle dogs were used as study subjects. The mandibular second and fourth premolars were extracted prior to the experimental surgery, and the extraction sites were allowed to heal for 8 weeks. After periodontal probing,...