Tryptophan injected in large quantities (500-1000 mg/kg) causes a statistically significant rise in the pyridine nucleotide content of livers from animals bearing Ehrlich ascites tumor but there is no corresponding rise in tumor nicotinamide adenine dinucleotide (NAD). Similarly, incorporation of isotope from ring-labeled tryptophan into the nicotinamide moiety of NAD occurs rapidly in host liv...

The accumulation of imidazoleglycerol phosphate during growth of Neurospora crassa in the presence of 3-amino-1,2,4-triazole was found to cause derepression of tryptophan synthetase and to inhibit the induction of kynureninase. Accumulation of indoleglycerol phosphate in response to growth in the presence of indole acrylic acid or anthranilic acid was also accompanied by derepressed synthesis o...

Furosemide (FUR) is an anthranilic acid derivative which is a potent diuretic widely used in the treatment of congestive heart failure and edema. FUR works by blocking the absorption of salt and fluid in the kidney tubules, causing a profound increase in urine output (diuresis). Due to the considerable use of FUR, analytical determination is frequent. In this manuscript, a review of the methods...

Emission Mössbauer spectroscopy with the Co isotope was used to study very dilute rapidly frozen aqueous solutions of cobalt(II) complexes with low-molecular-weight biomolecules (aromatic amino acids – anthranilic acid and L-tryptophan) and within a sophisticated biopolymer, bacterial glutamine synthetase, a key enzyme of nitrogen metabolism. The appearance of after-effects of the Co→Fe nuclear...

Lactobacillus arabinosus has the ability to synthesize several amino acids when adequate quantities of vitamin Bg are included in the medium (1, 2) ; however, the requirement of this organism for tryptophane is apparently not affected by the addition of vitamin 136 (2). Earlier studies showed that indole and anthranilic acid have appreciable tryptophane activity for L. arabinosus (3-7) but not ...

Dysregulation of Trp-Kyn pathway is the most recent hypothesis of mechanisms of schizophrenia. In particular, over-production of kynurenic acid (KYNA), one of the three immediate downstream metabolites of kynurenine (Kyn) along tryptophan (Trp): Kyn pathway, has been considered as a new target for therapeutic intervention in schizophrenia. Up-regulation of KYNA formation was suggested to occur ...