Anti-D immunoglobulin is now widely used to prevent Rh-negative mothers from being sensitized by Rh-positive fetal erythrocytes. The administration of anti-D following the transfusion of large amounts of Rh-positive erythrocytes into Rh-negative individuals has been less uniformly successful in preventing primary immunization (Bowman and Chown, 1968), and occasional mild (Woodrow et al, 1968) o...

In December 2012, the Food and Drug Administration (FDA) approved VariZIG, a varicella zoster immune globulin preparation (Cangene Corporation, Winnipeg, Canada) for use in the United States for postexposure prophylaxis of varicella for persons at high risk for severe disease who lack evidence of immunity to varicella* and for whom varicella vaccine is contraindicated. Previously available unde...

Antithymocyte/antilymphocyte globulins are polyclonal antihuman T-cell antibodies used clinically to treat acute transplant rejection. These reagents deplete T cells, but a rabbit antihuman thymocyte globulin has also been shown to induce regulatory T cells in vitro. To examine whether antithymocyte globulin-induced regulatory cells might be functional in vivo, we generated a corresponding rabb...

Syphilitic anti-lipoidal antibodies as detected by the standard tests for syphilis (STS) are usually recovered in both yM (19S) and yG (7S) globulin fractions (Davis, Moore, Kabat, and Harris, 1945; Laurell and Malmqvist, 1961; Aho, 1967), whereas substances responsible for biologic false positive (BFP) reactions are found in most instances solely in the yM globulin fraction (Aho, 1968). Syphil...

Antithrombin activities in 30 severely malnourished children and 40 normal children were estimated in clotting tests by thrombin neutralisation as anti-Xa and by a heparin antithrombin assay; and by immunodiffusion as alpha 2-globulin and alpha 1-antitrypsin. The patients' mean alpha 2-globulin was severely depressed, and there were less marked depletions in mean values for thrombin neutralisat...

Corneal allografts, like other foreign tissues, are subject to immunologic attack and rejection. Efforts to prolong graft survival have included the use of antilymphocyte serum and blocking antibodies. In this study antilymphocyte serum was tested as a potential corneal allograftblocking reagent. It has been demonstrated that guinea pig anti-rabbit lymphocyte serum and the gamma globulin fracti...

Rabbit antibovine serum albumin antisera were fractionated by zone electrophoresis on starch, zone ultracentrifugation in sucrose density gradients, and diethylaminoethyl-cellulose chromatography, and were assayed by the passive HA technique. Antisera had at least two antibodies: one associated with a fraction characterized as a gamma-2 globulin with a sedimentation rate of 7.3S and low anionic...

The binding of purified 131I-3, 3', 5'-triiodothyronine (reverse T3) (rT3) to normal human serum components was investigated by a radioimmunoelectrophoretic technique. When anti-whole human serum was used, five distinct arcs of radioactivity were observed. Evidence was obtained that five of these radioactive arcs were not artifacts, but were due to components binding rT3. From the radioimmunoel...

OBJECTIVE The objective of the study was to investigate the association between maternal Rh D status, prenatal exposure to anti-D immune globulin, and the risk of autism in the offspring. STUDY DESIGN Case-control study among children born from 1995 to 1999 at Kaiser Permanente Northern California hospitals. Cases (n = 400) were children with an autism diagnosis; controls (n = 410) were child...