background: flavonoids have a variety of biological activities, such as anti-allergic, anti-inflammatory, anti-oxidative, free radical scavenging, and anti-mutagenic. methods: the cytotoxic effects of three synthesized flavonoid derivatives (k3, k4 and k5) were evaluated against hela , mda-mb -231 and ht-29 cancer cells using mtt assay. results: the results showed that these flavonoids were not...

Microalgae represent one of the most promising sources bioactive compounds for pharmaceutical and food industries. Among these bioactives, carotenoids could be highlighted due to their health-promoting effects, including anti-inflammatory, neuroprotective or antioxidant properties. In this study, diverse microalgae extracts enriched in carotenoids, from Haematococcus pluvialis, Nannochloropsis ...

The dermis is mainly constructed by type I collagen fibers, which provide mechanical strength to the skin building a frame-like structure, and elastic elasticity respond movements of skin. depletion fibers disappearance oxytalan are fiber, characteristic changes in photoaged Prostaglandin E2 (PGE2) one chemical mediators involved inflammation responsible for sunburn. Furthermore, it has been re...

results the infusion group had a lower plasma pai-1 level compared to the subcutaneous group at day 7 (11.3 ± 1.6 vs. 16.5 ± 4.2; p = 0.003). the urinary ngal level was lower in the infusion group at day 2 (131.3 ± 11.9 vs. 151.2 ± 20.6; p = 0.014); however, at day 7 the ngal level was decreased in the subcutaneous group as much as the infusion group and there was no significant difference betw...

Four new 1,2,3-triazole phthalimide derivatives with a potent anti-inflammatory activity have been synthesized in the good yields by the 1,3-dipolar cycloaddition reaction from N-(azido-alkyl)phthalimides and terminal alkynes. The anti-inflammatory activity was determined by injecting carrageenan through the plantar tissue of the right hind paw of Swiss white mice to produce inflammation. All t...

curcumin is a natural polyphenolic compound with anti-cancer, anti-inflammatory, and anti-oxidation properties. low water solubility and rapid hydrolytic degradation are two challenges limiting use of curcumin as therapeutic agent. in the current study, the role of the native/modified forms of bovine serum albumin (bsa) and casein, as food-grade biopolymers and safe drug delivery systems, on th...

the aim of the present study was to investigate the potential of nanoemulsion formulation for topical delivery of clobetasol propionate (cp) using algal oil (containing omega-3 fatty acids) as the oil phase. cp has anti-inflammatory, immunomodulatory and antiproliferative activities. however, its clinical use is restricted to some extent due to its poor permeability across the skin. algal oil w...

background : ulcerative colitis an inflammatory bowel disease (ibd) and chronically idiopathic immune related that associates with extraintestinal manifestations such as arthritis. despite of the highly specificity ofanti-cyclic citrullinated peptide (ccp) antibodies for rheumatoid arthritis, their role in ibd remains unclear . there are only a few studies on the prevalence of anti-ccp antibodi...

alzheimer's disease (ad) is a chronic neurodegenerative disease that accounts for 60 to 80 percent of all dementia cases. the exact cause of alzheimer`s disease is still unknown, but recent studies suggest neuro-inflammation as an important part of the pathogenesis of the disease. this brings in mind using non-steroidal anti-inflammatory drugs (nsaid) as treatment or prevention of the dise...