Reliable measurement of clinically relevant autoimmune antibodies toward phospholipid-protein conjugates is highly desirable in research and clinical assays. To date, the development in this field has been limited to the use of natural heterogeneous antigens. However, this approach does not take structural features of biologically active antigens into account and leads to low reliability and po...

the effect of anti-follicular stimulating hormone (fsh) on testicular lipid and the specific activity of testicular enzymes of the isocitrate dehydrogenase (icdh), pyruvate/malate dehydrogenase (mdh) and malic enzyme involved in lipogenesis were studied in mature bonnet monkeys, macaca radiata. immunization of monkey with anti-fsh for 24 days did not produce any significant changes in the body ...

OBJECTIVE Prothrombin (PT) is one of the most important antigenic targets for aPL antibodies; however, the prothrombotic mechanism of anti-PT (aPT) antibodies in APS is not fully clarified. Considering that some autoantibodies possess the enzymatic activity, the aim of this study was to test the hypothesis that some aPT antibodies in APS may display prothrombinase activity. METHODS Six APS pa...

Background: Immunopathological and inflammatory processes play important roles in the initiation and development of Ischemic Heart Disease (IHD). Objective: The aim of this study was to evaluate the serum levels of several autoantibodies including rheumatoid factor (RF), anti-nuclear antibodies (ANA), anti-small nuclear ribonucleoprotein (anti-Sm), anti-phosphatidylserine (anti-PS) and anti-car...

kIU/L; normal values 18 kIU/L) autoantibodies, and 2 were negative for all anti-phospholipid antibodies investigated by the ELISA method. Thus, the new SCT assay was positive in 87% of those who had a positive result by our LA test and was negative in 93% of those whose results were negative by our LA assay. All of these patients had histories of thromboembolic disease (4 with venous thrombosis...

cd19 is expressed on b- lineage cells and follicular dendritic cells and plays a key role in b cell malignancies and autoimmune diseases. thus, it has been considered as potential target for several monoclonal antibodies (mabs). for decades, chemotherapy has been known as one of the major antitumor therapies eradicating high proliferative tumor cells. but, anti- cd19 mabs developed for treating...

BACKGROUND AND OBJECTIVES Difficulties in identifying the coexistence of neutralizing anti-factor VIII antibodies (anti-fVIII) and lupus anticoagulant (LA) are mainly due to the interference of LA on anti-fVIII assays. Our aim was to reveal the presence of anti-fVIII using a system that is not affected by LA. DESIGN AND METHODS We developed an enzyme-linked immunosorbent assay (ELISA) method ...

Patients with malignancy are at higher risk of thrombotic complications due to the hypercoagulability state. Our objective in this study was to assess the serum concentrations of Homocysteine, anti phospholipid antibodies, and anti cardiolipin in patients with benign and malignant breast tumors and study the effect of chemotherapy on the serum levels of these markers. A case control study was c...