BACKGROUND The aim of our present study was to establish new reference intervals for thyrotropin (TSH) and thyroid hormones based on National Academy of Clinical Biochemistry (NACB) criteria and regular thyroid ultrasonography. We also assessed the effect of potentially confounding factors to modulate the limits of these intervals. METHODS We investigated 870 apparently healthy persons and ex...

The dependent tumors exhibited minor chromosomal changes and thyroglobulin antigenicity similar to that of normal rat thyroid. The transitional tumors exhibited moderate chromosomal alterations and practically no thyroglobulin antigenicity. The autonomous tumors exhibited severe chromosomal alteration, numerically and/or structurally, and no detectable immunogenicity related to thyroglobulin. A...

Background: Serum thyroglobulin appears to be a sensitive marker of thyroid dysfunction in endemic goiter. However, its value as an indicator of thyroid status in children after the introduction of iodized salt has not been tested. Objective: The objective was to optimize and validate a thyroglobulin assay on dried whole blood spots and to evaluate thyroglobulin as an indicator of thyroid respo...

BACKGROUND AND PURPOSE Washout thyroglobulin provides evidence for metastatic or recurrent lesions, However, the cutoff value is still controversial. We investigated an optimized cutoff value and indication for the use of washout thyroglobulin from fine-needle aspiration in neck lymph nodes from preoperative or postoperative patients with well-differentiated thyroid cancers. MATERIALS AND MET...

Thyroid tissue obtained from 12 patients with Graves' disease and treated with thionamide drugs for 3-7 mo before subtotal thyroidectomy, from 12 patients with Graves' disease, similarly treated, and given 50 mug of triiodothyronine (T3) for 10 days before surgery, and from 12 euthyroid patients with solitary cold nodules was investigated to compare in vitro iodination of thyroglobulin in toxic...

background: infections attributed to helicobacter pylori ( h. pylori ) involve almost half of the world's population. one of the effects is auto-antibody induction and cross-reaction with numerous proteins in the body. as a result of its widespread prevalence and importance, this study evaluates the associations between h. pylori and thyroid auto-antibodies. materials and methods: this study en...

Background: One of the most common endocrine problems in major beta-thalassemia is hypothyroidism (HT). The aim of this study was to evaluate thyroid function status in major beta-thalassemia patients older than 10 years old. Methods: This cross sectional study was carried out on thalassemia major patients registered on Thalassemia Center of Amirkola Children Hospital in Babol. A questionnaire ...