OBJECTIVE To describe the clinical characteristics of patients with spontaneous hypothyroidism, the frequency of chronic autoimmune thyroiditis, and the thyroid autoantibody most often associated with this condition in a referral population in Jamaica. METHODS A retrospective study of all cases referred to the author's endocrinology practice from 1995 to 2005 with a diagnosis of spontaneous h...

Postpartum thyroid dysfunction (PPTD) is a common disorder which causes considerable morbidity in affected women. The availability of effective treatment for hypothyroid PPTD, the occurrence of the disease in subsequent pregnancies and the need to identify subjects who develop long term hypothyroidism, has prompted discussion about screening for this disorder. There is currently no consensus ab...

Iodination of the isolated thyroglobulin (Tg) by peroxidase was compared with various Tg preparations obtained from patients with thyroid diseases. For the purpose, the iodination process was observed in the incubation medium containing Tg, iodide, H2O2-generating system, and thyroid peroxidase (TPO) or lactoperoxidase (LPO). During the incubation, iodination of Tg preparations increased gradua...

The relationship between mood disorders and abnormalities of the endocrine and immune systems have been described (Horning et al. 1998, Kanba et al. 1998). Thyroid abnormalities associated with lithium treatment have been widely reported, including goiter, hypothyroidism, hyperthyroidism, and autoimmune thyroiditis (Kibirige et al. 2013). The presence of antithyroid antibody titers in bipolar p...

We herewith describe a patient with acute confusion, expressive aphasia and generalized seizures. A through workup excluded most causes of encephalopathy. He was, however, found to have TSH=18.6 MIU/ml, T3reverse=0.44nmol/L, T4=0.8ng/dl and Anti-Thyroid-Peroxidase AB titer >1000 IU/ml. Based on the above findings the patient was diagnosed with Hashimoto's encephalopathy and his mental status sh...

BACKGROUND Thyroid function test results of healthy pregnant women differ from those of healthy non-pregnant women. This study aimed to determine trimester-specific reference ranges for total tetraiodothyronin (T4), free T4, total triiodothyronin (T3) and thyroid stimulation hormone (TSH) using electrochemiluminescence techniques from apparently healthy pregnant women in Basrah. MATERIAL AND ...

Unilateral proptosis and ptosis in euthyroid Graves’s disease is very rare with 5 -10% cases reported. We present a clinically Euthyroid male with features of thyroid ophthalmopathy who presented with unilateral proptosis and ptosis, restriction of extra ocular movements and compressive optic neuropathy. Thyroid function tests were normal and anti-thyroid peroxidase antibody was positive. CT sc...

BACKGROUND & OBJECTIVES Several autoimmune disorders have been reported to be associated with autoimmune thyroiditis and may coexist with other organ-specific autoantibodies. The aim of the present study was to evaluate the presence of tissue transglutaminase (anti-TTG) and glutamic acid decarboxylase (anti-GAD) antibodies in patients suffering from autoimmune thyroiditis as diagnosed by anti-t...

BACKGROUND AND OBJECTIVES Thyroid dysfunction is common in the elderly. We sought to explore thyroid hormone patterns in a series of elderly patients undergoing elective coronary procedures and their relation to the extent of coronary artery disease. MATERIALS AND METHODS We enrolled 81 consecutive elderly patients admitted to undergo elective diagnostic or interventional coronary procedures....