celiac disease is an autoimmune disorder that affected 1% of all population in united state. classic manifestations ofdisease consist of early childhood diarrhea, malabsorption, steatorrhea and growth retardation but disease can affects adult at any age. in adult anemia is a more frequent finding. this patient was a 40-year-old lady with progressive fatigue and lower extremities pitting edema. ...

OBJECTIVE To investigate the presence of autoantibody deposition against type 2 tissue transglutaminase (TG2; a reliable marker of the whole spectrum of gluten sensitivity) in the jejunal tissue and brain of patients with gluten ataxia and in control subjects. METHODS The authors evaluated jejunal biopsy samples from nine patients with gluten ataxia and seven patients with other causes of ata...

BACKGROUND Celiac disease (CD) occurs in as many as 1 in 80 pregnant women and is associated with poor pregnancy outcome, but it is not known if this is an effect on maternal nutrient absorption or, alternatively, if the placenta is an autoimmune target. The major autoantigen, tissue transglutaminase (tTG), has previously been shown to be present in the maternal-facing syncytiotrophoblast plasm...

The incidence of celiac disease is increasing worldwide, and human tissue transglutaminase has long been considered the autoantigen of celiac disease. Concomitantly, the food industry has introduced ingredients such as microbial transglutaminase, which acts as a food glue, thereby revolutionizing food qualities. Several observations have led to the hypothesis that microbial transglutaminase is ...

Tissue transglutaminase was reported to act as protein disulfide isomerase (PDI). We studied whether plasma transglutaminase - coagulation factor XIII (FXIII) - has PDI activity as well. PDI activity was measured by determining the ability to renature reduced-denatured RNase (rdRNase). We found that FXIII can renature rdRNase, with efficiency comparable to commercial PDI. This PDI activity was ...

The laminin-nidogen complex, a major component of basement membranes, incorporates [3H]putrescine and monodansylcadaverine in the presence of guinea pig liver transglutaminase. Label was detected in nidogen in the isolated, as well as in the complexed form, but not in laminin. The incorporation proceeds in a time-dependent manner at a rate similar to that achieved with N,N-dimethylcasein, a wel...

background we aimed to investigate the frequency of celiac disease in children with β-thalassemia major (b-tm) in shiraz, southern iran. materials and methods in this study, the prevalence of celiac disease in children with b-tm was evaluated. children with btm were screened for celiac disease by ant-tissue transglutaminase (anti-ttg) iga antibody, iga level and anti-ttg igg. a total of 1500 sc...

Background: Tissue type 2 transglutaminase (TG2, E.C. 2.3.2,13) is reported to be involved in the phagocytosis of apoptotic cells mouse microglial BV2 and peripheral macrophages. In this study, by using lipopolysaccharide (LPS)- or amyloid-β 1-42 (Aβ 1-42) peptide-stimulated cell line primary cells, we examined effects different neuronutraceutical compounds, such as curcumin (Cu) N-Palmitoyleth...