OBJECTIVES To study the prevalence of antibodies of IgA class against tissue transglutaminase (tTG), endomysium (EMA) and gliadin (AGA) in patients with chronic idiopathic axonal polyneuropathy (CIAP) and to characterize the patients clinically and neurophysiologically. METHODS Of 182 patients, 126 patients agreed to blood sampling. Sera were analysed by ELISAs detecting anti-tTG and AGA, whe...

eliac disease (CD) results from an abnormal response of the small bowel mucosa to gluten peptides derived from wheat. Classically, affected individuals have abdominal distension, malabsorption and diarrhea but in the last few years occult forms of the disease presenting with isolated iron deficiency anemia have been recognized.1 The disorder is more common in women, is familial and is associate...

PURPOSE Migration and adhesion of dislocated retinal pigment epithelial (RPE) cells to a fibronectin-rich extracellular matrix is an initial step in proliferative vitreoretinopathy (PVR). In the present study, the functional role of cell surface tissue transglutaminase (tTG) in adhesion and migration of RPE cells on fibronectin (Fn) and collagen type I (Col I) after stimulation with TGF-beta2 w...

The prevalence of celiac disease (CD) among Japanese population has been unknown, whereas it has been increasingly recognized in the US and in the European countries. The aim of the present study is to identify possible cases with CD among Japanese population and clarify the relevance of screening for the disease. We conducted a serologic screening for the disease among 710 Japanese patients an...

OBJECTIVE Type1 diabetes mellitus may be associated with celiac disease. The prevalence of celiac disease as determined by screening among adult patients with type 1 diabetes is high with rates of 1.07.8% in Europe and U.S.A. The aims of the study are to determine the prevalence of celiac disease in adults with type 1 diabetes in Tunisia. METHODS 348 consecutive adult patients with type1 diab...

Coeliac disease: it takes three to tango! Coeliac disease (CD), the most common food sensitive enteropathy in humans, is caused by permanent intolerance for dietary gluten. 1 2 Typical symptoms include chronic diarrhoea, abdominal distension, and failure to thrive. These symptoms are the result of a lesion in the upper small bowel characterised by (sub)total villous atrophy , hypertrophic crypt...

OBJECTIVE To analyze if it is worthwhile to screen Brazilian osteoporotic patients for celiac disease (CD). SUBJECTS AND METHODS One hundred patients with osteoporosis and 97 controls were evaluated for IgA-EmA (IgA anti-endomysial antibodies) by indirect immunofluorescence method and IgG-anti-tTG (tissue transglutaminase) by ELISA assay. Positive patients were invited to have gastrointestina...

background: northeast iran has one of the highest rates of esophageal cancer in the world which is mainly squamous cell carcinoma (e scc). celiac disease (cd) has been identified as a risk factor for escc. the aim of this study is to determine the prevalence of cd in gonbad at northeast iran and probable relation between celiac and escc. materials and methods: fourteen hundred inhabitants of no...

BACKGROUND Phage display antibody libraries have been made from the lymphocytes of patients suffering from autoimmune diseases in which the antibodies are known to play a role in the pathogenesis or are important for the diagnosis of the disease. In the case of Celiac Disease, the immune response is directed against the autoantigen tissue transglutaminase. However, despite numerous studies, the...