Background: Tuberculosis is an airborne infection that causes lung damage, and it particularly harmful to patients with weakened immune systems or other health problems. Allopathic medications are associated development of cross resistance multidrug in diseases such as TB, making treatment more difficult. In this case, Herbal remedies the most effective treating disease. Medicinal plants antitu...

objective(s) aristolochia indica has been widely used in the traditional medicine for the treatment of a variety of diseases. in the present study different extracts of roots of a. indica were evaluated for their anti­inflammatory, antipruritic and mast cell stabilizing activity. materials and methods anti-inflammatory activity was performed by compound 48/80 induced rat paw edema model and ant...

treatment of tuberculosis (tb) and the discovery of effective new anti tubercular drugs is one of the most urgent priorities in health organizations all around the world. in the present study, fluorinated analogs of some of the most important anti-tb agents such as p-aminosalicylic acid (pas), thiacetazone and pyrazinamide were synthesized and tested against tb. the fluorinated analog of thiace...

Many bacteria regulate gene expression in response to phosphate availability using a two-component signal transduction system, the activity of which is controlled by interaction with the Pst phosphate specific transporter and a cytoplasmic protein PhoU. Mycobacterium tuberculosis, the causative agent of tuberculosis, requires its phosphate sensing signal transduction system for virulence and an...

Pyridazine plays a significant role in pharmaceuticals particularly in the field of medicinal chemistry. Several 4-substituted-benzylidene-6-substituted-phenyl-dihydro-pyridazin-3(2H)-one derivatives (3a-q) were synthesized and evaluated for their antimicrobial activities with an aim to obtain promising antitubercular agents. In the first step, 6-aryl-tetrahydro-pyridazin-3-ones (2) were prepar...

The musculoskeletal extrapulmonary tuberculosis is uncommon, the upper extremity tuberculosis is not common and the mycobacterial involvement of skin of hands and synovial sheath of tendons is rare. This prospective observational study was undertaken between August 2014 and December 2015 in a tertiary referral hospital. Patients attending with suspected primary tuberculosis of soft tissue of th...

musculoskeletal tuberculosis accounts for 1-2% of all types of tuberculosis. tubercular abscess of the chest wall accounts for 1-5% of all cases of musculoskeletal tuberculosis. herein, we report a case of tubercular abscess of the chest wall. the occurrence of caries rib and cold abscess of the chest wall with concomitant pulmonary tuberculosis, and tubercular lympha-denitis of neck and medias...

pseudotumour is a benign inflammatory lesion. mycobacterial spindle cell pseudotumour (msp) is a rare pseudotumour. it is a benign proliferation of spindle-shaped histiocytes containing acid-fast mycobacterium, commonly reported in immunocompromised patients. msp is usually associated with mycobacterium avium complex (mac). here, we present the case of a 38-year-old gentleman with acquired immu...

BACKGROUND A choroidal mass or granuloma is a feature of ocular tuberculosis (TB). Tubercles can arise in the early stages of progression of TB and indicate hematogenous dissemination before the development of symptomatic disease. Tubercular subretinal granuloma is responsive to treatment with anti-tuberculosis therapy, and prompt treatment helps resolve the lesion completely. FINDINGS We rep...

A 53 year old diabetic male, who was on anti – tubercular treatment, presented with an expansile swelling on his chest, at the intercostal drainage (ICD) site. He was diagnosed to have a left sided tubercular hydro – pneumothorax, about six weeks earlier. He had noticed the swelling at the ICD site, 5 days ago and he had no pain. Clinically, an expansile swelling of size 5 x 4 cm, was seen at t...