نتایج جستجو برای: anti tumor activity
تعداد نتایج: 1757450 فیلتر نتایج به سال:
Purpose Agonistic CD40 antibodies generate strong tumor specific CD8 T cell response and anti-tumor activity; however systemic anti-CD40 therapy has been associated with cytokine release syndrome and liver toxicity. We studied the anti-melanoma activity and mechanism of action of a recombinant adenovirus expressing a stabilized version of CD40L (rAd.CD40L) by local intratumoral delivery approac...
In the present study, we prepared NGR-modified sterically stabilized liposomes containing paclitaxel (NGR-SSL-PTX) in order to evaluate their potential targeting to aminopeptidase N receptors expressed on tumor endothelial cells and the tumor cell surface and its anti-angiogenic activity following metronomic administration. NGR-SSL-PTX was prepared by a thin-film hydration method. The in vitro ...
it has been reported that several members of convolvulaceae family such as convolvulus arvensis possess cytotoxic activity on some tumor cell lines. proteoglycan mixture, the water extract of c. arvensis with high molecular weight, has potent anti-angiogenesis and stimulating effects. in this study, arial parts of c. arvensis were collected and identified, and the cytotoxic effects of chlorofor...
Abstract Background Immune checkpoint blockade (ICB)-based cancer immunotherapy presents promising efficacy in treatment. However, only a small portion of patients show responsiveness to the treatment, which is partially caused by limited tumor infiltration T cells. Chemokines CXCL9, CXCL10 and CXCL11 bind their receptor CXCR3 regulate cell invasion. Methods We delivered plasmids encoding cells...
In spite of its long history, immunotherapy of cancer has led to only a few regulatory approved treatments, starting with interleukin (IL)-2 in renal cancer and melanoma and interferon in melanoma. Sipuleucel-T was approved for castrateresistant prostate cancer in 2010 and ipilimumab and pegylated interferon-α2b in 2011 for the treatment of metastatic and adjuvant melanoma respectively. Evidenc...
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