New coordination complexes of Co, Ni and Zn with Schiff base N’-((2-thioxo-1,2-dihydroquinoline-3yl)methylene) pyridine-4-carbohydrazide have been synthesized and characterized by several techniques using elemental analysis (C, H, N), IR spectra and 1HNMR spectra. The new Schiff base has been synthesized by the reaction of pyridine-4-carbohydrazide and 2-thioxo-1,2dihydroquinoline-3-carbaldehyd...

Peptoids are peptidomimetic polymers that are resistant to proteolysis and less prone to immune responses; thus, they can provide a practical alternative to peptides. Among the various therapeutic applications that have been explored, cationic amphipathic peptoids have demonstrated broad-spectrum antibacterial activity, including activity towards drug-resistant bacterial strains. While their po...

Objective: To learn about ADRs of antibacterial drugs in our Hospital and to provide references for rational drug use. Methods: Conduct retrospective studies, classification statistics, analysis and assessment on 469 ADR reports of antibacterial drugs collected between January 2015 and December 2016 in the hospital. Register ADR’s names, levels, results, drugs’ names, routes of administration, ...

Increasing resistance to antibacterials is a major public health problem. Antibacterial use is considered to be the main selective pressure driving this resistance, and the rate at which resistance develops has been shown to be associated with drug consumption. It has been suggested that reductions in the development of resistance will only result from significant changes in antibacterial use. ...

Due to the inexorable invasion of our hospitals and communities by drug-resistant bacteria, there is a pressing need for novel antibacterial agents. Here we report the development of a sensitive and robust but low-tech and inexpensive high-throughput metabolic screen for novel antibiotics. This screen is based on a colorimetric assay of pH that identifies inhibitors of bacterial sugar fermentat...

The antibacterial activity of ethanol extract of Zingiber officinale Roscoe (ginger) and its combination with different salts like CuSO4, ZnSO4 and MnCl2 was investigated. Both Gram positive and Gram negative bacteria were tested by agar diffusion method. The results showed that ethanol extract of Zingiber officinale gave the maximum zone of inhibition at 50mg/ml concentrations against Escheric...

Non-equilibrium plasmas offer several strategies for developing antibacterial surfaces that are able to repel and/or to kill bacteria. Due to the variety of devices, implants, and materials in general, as well as of bacteria and applications, plasma assisted antibacterial strategies need to be tailored to each specific surface. Nano-composite coatings containing inorganic (metals and metal oxid...

Objective: To synthesise a series of quinazolinone clubbed pyrazole derivatives and evaluate for their antibacterial activity. Method: Various Quinazolinone clubbed Pyrazole derivative compounds were synthesized as per standard chemical procedure and characterized by physical and spectral analysis. The antimicrobial activities of all the synthesized compounds were evaluated separately for their...