In the present study, antimicrobial activity of the ethanolic extract of propolis (EEP), collected at different periods (June, August, and October-November) from various regions (Taipei, Mingchien, and Fanglia) in Taiwan, against Staphylococcus aureus was investigated. The effects of cell age, incubation temperature, and pH in response to EEP were also investigated. Depending on concentration, ...

Microcos paniculata traditionally known as ‘Kathgua or Fattashi’ in Bangladesh is widely used for the treatment of various ailments including colds ,diarrhea, hepatitis, heat stroke, dyspepsia, wound healing, fever and as an insecticide. Hence, the present study was designed to investigate the antibacterial, toxicity & 4 th instar Culex quinquefasciatus mosquito larvicidal activities of fruit e...

OBJECTIVES Bacterial enoyl-ACP reductase (FabI) has been validated as a novel antibacterial target for tackling infections caused by multidrug-resistant pathogens. A few FabI inhibitors, however, are known. This study isolated a new FabI inhibitor from Penicillium sp. METHODS A screening programme led to the selection of a Penicillium sp. producing a strong FabI-inhibitory metabolite. The che...

The β-lactamase inhibitor avibactam (NXL104) displays potent inhibition of both class A and C enzymes. The in vitro antibacterial activity of the combination ceftazidime-avibactam was evaluated against a clinical panel of Pseudomonas aeruginosa isolates. Avibactam offered efficient protection from hydrolysis since 94% of isolates were susceptible to ceftazidime when combined with 4 μg/ml avibac...

The susceptibility of Streptococcus mutans to chlorhexidine and to six commonly used, systemic antibacterial agents (amoxicillin, cefuroxime, penicillin, sulfamethoxazole-trimethoprim, tetracycline, and erythromycin) was studied for 424 clinical isolates from 116 children and students. The MIC of chlorhexidine for all isolates was < or = 1 micrograms/ml. No resistance to the other antimicrobial...

Early availability of information on bacterial pathogens and their antimicrobial susceptibility is of key importance for the management of infectious diseases patients. Currently, using traditional approaches, it usually takes at least 48 hours for identification and susceptibility testing of bacterial pathogens. Therefore, the slowness of diagnostic procedures drives prolongation of empiric, p...

OBJECTIVE Quinolone resistance is usually caused by various chromosomal mutations, but has been more recently associated with plasmids which carry the qnr determinant. The aim of this study is to investigate the prevalence of qnr genes in clinical isolates of Enterobacteriaceae in Jamaica. METHODS A total of 255 non-duplicate fluoroquinolone-resistant Enterobacteriaceae clinical isolates, com...

WCK 771 demonstrated MIC(50) and MIC(90)s of 0.03 and 1 microg/ml, respectively, against 297 recent U.S. community-acquired and hospital strains of Staphylococcus aureus, irrespective of quinolone or glycopeptide resistance. Against quinolone-resistant strains, MIC(90)s of WCK 771 and moxifloxacin were 1 and 16 microg/ml, respectively.

We conducted a retrospective study of all hospitalized human immunodeficiency virus (HIV)-infected patients from whom a strain of Streptococcus pneumoniae was isolated (n = 45) between January 1992 and September 1994, in order to determine the clinical manifestations and outcome of and risk factors for infection by S. pneumoniae with decreased susceptibility to penicillin G. Such strains were i...