PURPOSE OF REVIEW Lung transplantation remains the main therapy for patients with end-stage lung disease, yet survival remains limited by infection and chronic rejection. Invasive fungal infection, especially invasive aspergillosis, continues to cause a high rate of mortality after lung transplantation, and there is evidence that fungal colonization in itself may have a negative impact as well....

Candida is the most common fungal pathogen of humans worldwide and has become a major clinical problem because of the growing number of immunocompromised patients, who are susceptible to infection. Moreover, the number of available antifungals is limited, and antifungal-resistant Candida strains are emerging. New and effective antifungals are therefore urgently needed. Here, we discovered a sma...

BACKGROUND In contrast to the increasing numbers of agents for the treatment of invasive fungal infections, discoveries of new antifungal agents with therapeutic value in dermatomycoses are reported only rarely. METHODS Abafungin (chemical abstracts service registry No. 129639-79/8) is the first member of a novel class of synthetic antifungal compounds, the arylguanidines. It was first synthe...

OBJECTIVES Fungi have been suspected of contributing to the pathogenesis of sarcoidosis. A previous intervention study demonstrated an improvement in the clinical condition in 15 out of 18 patients with a long-term history of sarcoidosis when antifungal medication was added to corticosteroids. The present study was performed to compare the effects of antifungal treatment with corticosteroid tre...

Phytochemical screening and antifungal activity test of jengkol leaf (Archidendron jiringa) extract have been carried out. The purpose this research is determine secondary metabolite content activities extract. Extraction was conducted with sequential extraction technique various solvent such as hexane, ethyl acetate methanol respectively. FTIR characterization show the presence O-H, C-H C-O C=...

OBJECTIVES The purpose of this study was to investigate the antifungal effect of bee venom (BV) and sweet bee venom (SBV) against Candida albicans (C. albicans) clinical isolates. METHODS In this study, BV and SBV were examined for antifungal activities against the Korean Collection for Type Cultures (KCTC) strain and 10 clinical isolates of C. albicans. The disk diffusion method was used to ...

objectives: belonging to papaveraceae family, glaucium vitellinum is one of the persian endemic plants which has not been investigated biologically. the present paper focused on the assessment of the antibacterial and antifungal activities of the total methanol extract and alkaloid sub-fraction of the flowering aerial parts of g. vitellinum. materials and methods: the antibacterial and antifung...

results the sequence analysis of the isolate confirmed as c. glabrata and deposited on ncbi genbank under the accession number no. kt763084-kt763123. the geometric mean mics against all the tested strains were as follows, in increasing order: casp (0.17 g/ml), vcz (0.67 g/ml), amb (1.1 g/ml), itz (1.82 g/ml), ktz (1.85 g/ml), and fcz (6.7 g/ml). the resistance rates of the isolates to casp, fcz...

The objective of our study is to implicate the mechanisms tolerance abiotic stress by synthesis metabolites in biotic stress. extracted metabolites; proline, sugars and polyphenols from durum wheat seedlings subjected heat shock (40 °C), used test antifungal activity on two fungal strains, powdery mildew penicillium, under controlled conditions. boussellam variety more tolerant applied than Cic...

Objectives: Belonging to Papaveraceae family, Glaucium vitellinum is one of the Persian endemic plants which has not been investigated biologically. The present paper focused on the assessment of the antibacterial and antifungal activities of the total methanol extract and alkaloid sub-fraction of the flowering aerial parts of G. vitellinum. Materials and Methods: The antibacterial and antifung...