* Tinea pedis (athlete's foot) occurs in about 15% ofthe population * Its usual treatment is a topical antifungal applied two or three times a day for up to four weeks * Terbinafine is a synthetic allylamine antifungal with a primarily fungicidal action against dermatophytes and some other moulds and yeasts * This study shows that terbinafine 1% cream applied twice daily for a week was signific...

The emergence of drug resistance in microbial pathogens provides a poignant example of an evolutionary process with a profound impact on human health. Fungal drug resistance poses a particular concern given the limited number of clinically useful antifungal drugs and the growing population of immunocompromised individuals vulnerable to life-threatening fungal disease [1]. The efficacy of most a...

management of cryptococcal disease. Clin Infect Dis 2000; 30: 710–8. 3. Sable CA, Strohmaier KM, Chodakewitz JA. Advances in antifungal therapy. Annu Rev Med 2008; 59: 455–73. 4. Baddley JW, Pappas PG. Antifungal combination therapy. Drugs 2005; 65: 1461–80. 5. Sionov E, Mendlovic S, Segal E. Efficacy of amphotericin B or amphotericin B-intralipid in combination with caspofungin against experim...

Antifungal activity of ethanol-water extracts of four medicinal plants, cinnamon (Cinnamomum verum Presl.), anise (Pimpinella anisum L.), black seed (Nigella sativa L.) and clove (Syzygium aromaticum L. Merr. & Perry.) was investigated against pea (Pisum sativum L.) root-rot fungus Rhizoctonia solani. In vitro antifungal activity test shown a high growth inhibition at concentration (4%) of each...

ABSTRACT New antifungals are needed, particularly in the developing world, to treat life-threatening fungal infections, such as cryptococcosis. Drug repurposing is one strategy to identify new drug-like compounds, but it is often difficult to identify a mechanism of action. Here we discuss the outstanding effort by Butts et al. to identify calmodulin as an antifungal target of repurposed estrog...

Nine oxylipin mimics were designed and synthesized starting from d-mannose. Their antifungal activity against three citrus postharvest pathogens was evaluated by spore germination assay. The results indicated that all the compounds significantly inhibited the growth of Penicillium digitatum, Penicillium italicum and Aspergillus niger. The compound (3Z,6Z,8S,9R,10R)-octadeca-3,6-diene-8,9,10-tri...

Persistent or recurrent unexplained fever in neutropenic patients receiving antibiotics can be caused by invasive fungal infections, which are often difficult to diagnose. Early trials of empirical antifungal therapy with amphotericin B deoxycholate (AmB) documented reductions in the frequency of and the morbidity and mortality associated with invasive fungal infections. Because of AmB's infusi...

OBJECTIVES To evaluate the efficacy of pH-sensitive liposomes of nystatin against Cryptococcus neoformans infection in a murine model. METHODS In the present study, we investigated the antifungal activity of nystatin entrapped in pH-sensitive liposomes in a murine model. Mice infected with C. neoformans were treated with nystatin in neutral egg phosphatidylcholine (egg-PC) liposomes, as well ...

Invasive fungal infections (IFIs) represent significant complications in patients with hematological malignancies. Chemoprevention of IFIs may be important in this setting, but most antifungal drugs have demonstrated poor efficacy, particularly in the prevention of invasive aspergillosis. Antifungal prophylaxis in hematological patients is currently regarded as the gold standard in situations w...

This research is reports the fungicidal properties of nano-size silver/chitosan nanoformulations (NFs) used as an agent for antifungal treatment of various seed borne plant pathogens. Fungal phytopathogens, especially seed borne disease causing species, Rhizoctonia solani, Aspergillus flavus, Alternaria alterneta were isolated form chickpea seeds. Differences were observed in the antifungal act...