The fungus of the genus Trichoderma is characterized by high biological activity and ability to synthesize many compounds great scientific interest. Among them, producers amino acids, nucleic organic vitamins, surface-active substances, numerous hydrolases, various antibiotics other substances were revealed. In this work there studied volatile produced asperellum Uz-A4, isolated from soil cotto...

According to the latest EU regulations it is necessary cut down consumption of chemically based pesticides. Several research programmes are focussed on study secondary metabolites plants, which have antimicrobial or antifungal activity against microbial phytopathogens. Other reasons for using natural biocides growth resistance phytopathogens several pesticides; broaden attacks significant agric...

Indigenous strains of Trichoderma species isolated from rhizosphere soils of Tea gardens of Assam, north eastern state of India were assessed for in vitro antagonism against two important tea fungal pathogens namely Pestalotia theae and Fusarium solani. A potent antagonist against both tea pathogenic fungi, designated as SDRLIN1, was selected and identified as Trichoderma viride. The strain als...

A common consequence of using agricultural fungicides is the development of resistance by fungal pathogens, which undermines reliability of fungicidal effectiveness. A potentially new strategy to aid in overcoming or minimizing this problem is enhancement of pathogen sensitivity to fungicides, or "chemosensitization." Chemosensitization can be accomplished by combining a commercial fungicide wi...

Adverse cardiac effects are a known, albeit infrequent, complication of azole antifungal drug therapy. Most often, cardiotoxicity is the result of drug–drug interactions due to azole inhibition of CYP3A4, but also of CYP2C19 and CYP2C9, leading to increased serum levels of concomitantly administered medications that require hepatic metabolism. Adverse interactions of azole antifungal drugs with...

Cyanobacterial secondary metabolites have a diverse antagonistic activity that lead to disintegration of microbial growth. The study was conducted to evaluate the antifungal property possessed by cyanobacteriaAnabaena variabilis in retarding the growth of plant pathogenic fungal species. It was observed that the extracts prepared from Anabaena variabilis were capable of diminishing the growth a...

After decades of intensive searching for antimicrobial compounds derived from actinobacteria, the frequency of isolation of new molecules has decreased. To cope with this concern, studies have focused on the exploitation of actinobacteria from unexplored environments and actinobacteria symbionts of plants and animals. In this study, twenty-four actinobacteria strains isolated from workers of Tr...

Aspergillus fumigatus is a well adapted, opportunistic fungus that causes a severe and commonly fatal disease, invasive pulmonary aspergillosis (IPA), in highly immunocompromised patients, aspergilloma in patients with lung cavities and allergic bronchopulmonary aspergillosis (ABPA) in hypersensitive individuals. Recent studies have suggested that biofilm formation by A. fumigatus may be one of...

Among thirty four endophytic fungal strains screened for in vitro antagonism, the endophytic fungus Cordyceps dipterigena was found to strongly inhibit mycelial growth of the plant pathogenic fungus Gibberella fujikuroi. Two new depsidone metabolites, cordycepsidone A (1) and cordycepsidone B (2), were isolated from the PDA culture extract of C. dipterigena and identified as being responsible f...

Different kinds of mycoses, especially invasive, have become an important public health problem as their incidence has increased dramatically in the last decades in relation to AIDS, hematological malignancies, transplant recipients and other immunosuppressed individuals. Management of fungal infections is markedly limited by problems of drug safety, resistance and effectiveness profile. Curren...