Doxazosin is an α1 adrenergic receptor blocker that also exerts antitumor effects. However, the underlying mechanisms by which it modulates PI3K/Akt intracellular signaling are poorly understood. In this study, we reveal that doxazosin functions as a novel antiangiogenic agent by inhibiting vascular endothelial growth factor (VEGF)-induced cell migration and proliferation. It also inhibited VEG...

Pistacia atlantica (wild pistachio) belongs to the Anacardiaceae family, and growing from Mediterranean basin central Asia, especially in Iran, Turkey, Iraq Saudi Arabia where it is extensively used traditional medicine for a wide range of ailments related relieving upper abdominal discomfort pain, dyspepsia peptic ulcer. Despite diverse biological activities P. atlantica, there no current revi...

BACKGROUND & OBJECTIVE Hypertension is a major risk factor for cardiovascular and renal diseases. In PR China, the prevalence of hypertension has substantially increased during the past four decades. Information on prevalence as well as awareness regarding treatment and prevention of hypertension is scarce particularly in rural settings. The objective of this study was therefore to estimate the...

Gram-positive facultative anaerobic microorganisms that produce large amounts of lactic acid. LAB, which are seen in milk and the human intestine, are used for the manufacture of yogurt and cheese. They are referred to as animal-derived LAB. On the other hand, LAB exist on the surface of fruits, vegetables, and flowers. These LAB, designated plant-derived LAB, have higher adaptation characteris...

OBJECTIVE To measure adherence and to identify factors associated with adherence to antihypertensive medications in family practice patients with diabetes mellitus (DM) and hypertension. DESIGN A cross-sectional study using a mailed patient self-report survey and clinical data. SETTING Twenty-seven family physician and nurse practitioner clinics from Nova Scotia, New Brunswick, and Prince E...

BACKGROUND Benzodiazepine use by elderly patients is associated with adverse outcomes including increased risk of falls and fractures, motor vehicle accidents and cognitive impairment. Recent studies suggest that individualized feedback and education to physicians may improve drug prescribing. In this study, we evaluated an intervention to address the inappropriate prescribing of benzodiazepine...

BACKGROUND Due to excellent performance in antitumor, antioxidation, antihypertension, antiatherosclerotic and antidepressant activities, crocetin, naturally exists in Crocus sativus L., has great potential applications in medical and food fields. Microbial production of crocetin has received increasing concern in recent years. However, only a patent from EVOVA Inc. and a report from Lou et al....

FOR CHRONIC MEDICAL CONDITIONS, SUCH AS HYPERcholesterolemia and hypertension, a wide and persistent separation exists between evidence-based recommendations and the actual care patients receive. Reasons for this gap are not always clear, but some components are obvious, including failing to identify patients in need of treatment, not properly initiating treatment, failing to provide proper dru...

BACKGROUND The new guidelines issued by the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC 7) emphasize that aggressive blood pressure (BP) control is essential to reducing morbidity and mortality. Additionally, guidelines issued by the American Diabetes Association (ADA) and the World Health Organization-International Society of Hyperte...