background: the widespread utilization of antimicrobial compounds has caused emergence of resistant microorganisms in the world. hence, the research to probe the products with antimicrobial features has led to finding natural habitats and discovering new pharmaceutical products. methods: in this study, an attempt was made to explore the niche of novel habitat to isolate pyllospheric bacteria fr...

voriconazole is an antifungal triazole, approved for management of invasive fungal diseases in patients. it is absorbed during two hours and its serum levels will be above 90%, based on the underlying factors, when the drug is administered orally. voriconazole shows a propotional increase in an area under the plasma concentration-time curve (auc), with increasing dose. plasma protein binding of...

the dorsal skin of the iranian frog, rana ridibanda, is associated with numerous prominent granular glands which extract their secretions in the response to stressor or invading pathogens .the secretions have broad spectrum antimicrobial effects. in this research the effect of antimicrobial skin secretions from iranian frog (rana ridibanda) has been examined against gram positive methycillin re...

Introduction Therapeutic Drug Monitoring (TDM) is an evolving tool used to optimise the administration of antimicrobial agents; which are well documented to have toxic side effects [1]. In combination with increasing antimicrobial resistance and emphasis on cost-efficiency, provision of the optimal dose of antimicrobial therapy is a very attractive prospect. Pharmacokinetic (PK) indices can be ...

abstract background and purpose: in traditional medicine, herbal products still remain the principal source of pharmaceutical agents. the present study aimed to investigate the antifungal effects of echinophora platyloba and rosmarinus officinalis extracts on c. albicans species. materials and methods: the aqueous and ethanolic leaf extracts of e. platyloba and r. officinalis, collected from th...